Applications

The discovery that differentiated tissue cells can transform into embryonic-like stem cells, known as inducible pluripotent stem cells (iPS), marked a pivotal scientific breakthrough, earning the Nobel Prize in 2012. Induced pluripotent stem cells provide an exciting alternative preventing ethical issues associated with embryonic stem cells derived from human embryos. In 2008 "Reprogramming Cells" was designated 'Breakthrough of the Year' by the journal Science with specific mentioning of the Tet Technology in the corresponding editorial. Since then, the Tet Technology was successfully applied becoming an integral part of the reprogramming process. Tet Technology helped to further advance the iPS field as an essential technology to control expression of reprogramming factors. Ideally the Tet Technology can be combined with other Stem Cell technologies.

Recent Literature: 

Pawlowski et al. (2017) Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes: Stem Cell Reports 2017 Apr; 8(4); 803-812

Takahasi and Yamazaki (2019) Generation of a human induced pluripotent stem cell line, IMSUTi002-A-1, harboring the leukemia-specific fusion gene ETV6-RUNX1: Stem Cell Reports 2019 Oct; 40; 1 -4