Applications

Conventional transgenic and knockout animals, while widely used for research and disease modelling, suffer from limitations such as embryonic lethality and irreversible gene deletions. The Tet Technology addresses these challenges by enabling tight, time- and tissue-specific, reversible control of gene expression in vivo. Tet transgenic mouse models played a crucial role in understanding diseases such as Diabetes Type I, Asthma, Alzheimer's, and Huntington's, demonstrating the potential of the Tet gene switch in reversing pathological states.

Recent Literature: 

Karg et al. Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma; Cell Reprogram. 2023 Dec;25(6):288-299.

Jin et al. (2022) Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression. Sci China Life Sci. 2022 Nov;65(11):2269-2286