Transgenic Mouse Lines
The following tables comprise mouse lines expressing the Tet transactivators (tTA [Gossen and Bujard, 1992] rtTA [Gossen et al., 1995] rtTA2 S-M2 or rtTA2 S-S2 [Urlinger et al., 2000]) under control of various promoters (Table 1) and responsive mouse lines carrying target genes under Tet-control (Table 2). Commercial Partners, Licensees and Members (registered users) will have access to the complete Tables 1 and 2.
These lists may not be complete as the list of Tet mice is continuously increasing. Therefore, if you are aware of additional mouse lines that should be included, please contact us. The tables will be updated on a regular basis and are a service that we provide to the research community.
For scientists receiving requests for Tet mice, please find the Notice and Acknowledgement Agreement (N&A) that has to be completed before Tet mice can be transferred to eecipients. Please click on N&A 1 if the requesting institution is governed by the Federal Tort Claims Act (FTCA 28 U.S.C.). For all other institutions, please use N&A 2.
Table 1: Mouse lines expressing tTA or rtTA genes
| Promoter (origin) | Tissue specificity | tTA/ | rtTA | References |
|---|---|---|---|---|
| Albumin / MUP (mouse urinary protein) | Liver | + |
||
| astrocyte-specific glial fibrillary acidic protein | neuronal cells | + |
||
| ... | ... | ... |
... |
... |
Table 2: tTA / rtTA responsive mouse lines
| Genes under Tet Control | |
|---|---|
| Reporter Genes | References |
| Fluorescent Calcium indicator Proteins: Cg2 (camdaroo 2); IP (inverse pericam); YC3.12 (yellow cameleon) |
Hasan MT et al. 2004 |
| Luciferase (L7) | Kistner A et al (1996) |
| ... | ... |

