Leadership In Controlled Gene Expression

Affaitati, A., Cardone, L., de Cristofaro, T., Carlucci, A., Ginsberg, M. D., Varrone, S., Gottesman, M. E., Avvedimento, E. V., and Feliciello, A. (2003). Essential Role of A-kinase Anchor Protein 121 for cAMP Signaling to Mitochondria. J Biol Chem 278, 4286-4294.

Afroze, T., Yang, L. L., Wang, C., Gros, R., Kalair, W., Hoque, A. N., Mungrue, I. N., Zhu, Z., and Husain, M. (2003). Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle. Am J Physiol Cell Physiol 285, C88-95.

Aglipay, J. A., Lee, S. W., Okada, S., Fujiuchi, N., Ohtsuka, T., Kwak, J. C., Wang, Y., Johnstone, R. W., Deng, C., Qin, J., and Ouchi, T. (2003). A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 22, 8931-8938.

Akeson, A. L., Greenberg, J. M., Cameron, J. E., Thompson, F. Y., Brooks, S. K., Wiginton, D., and Whitsett, J. A. (2003). Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Developmental Biology 264, 443-455.

Akiri, G., Sabo, E., Dafni, H., Vadasz, Z., Kartvelishvily, Y., Gan, N., Kessler, O., Cohen, T., Resnick, M., Neeman, M., and Neufeld, G. (2003). Lysyl Oxidase-related Protein-1 Promotes Tumor Fibrosis and Tumor Progression in Vivo. Cancer Res 63, 1657-1666.

Akiyama, H., Sugiyama, A., Uzawa, K., Fujisawa, N., Tashiro, Y., and Tashiro, F. (2003). Implication of Trip15/CSN2 in early stage of neuronal differentiation of P19 embryonal carcinoma cells. Developmental Brain Research 140, 45-56.

Akiyama, H., Fujisawa, N., Tashiro, Y., Takanabe, N., Sugiyama, A., and Tashiro, F. (2003). The Role of Transcriptional Corepressor Nif3l1 in Early Stage of Neural Differentiation via Cooperation with Trip15/CSN2. J Biol Chem 278, 10752-10762.

Aleman, C., Annereau, J.-P., Liang, X.-J., Cardarelli, C. O., Taylor, B., Yin, J. J., Aszalos, A., and Gottesman, M. M. (2003). P-Glycoprotein, Expressed in Multidrug Resistant Cells, Is Not Responsible for Alterations in Membrane Fluidity or Membrane Potential. Cancer Res 63, 3084-3091.

Alfke, H., Stoppler, H., Nocken, F., Heverhagen, J. T., Kleb, B., Czubayko, F., and Klose, K. J. (2003). In Vitro MR Imaging of Regulated Gene Expression. Radiology 228, 488-492.

Aminev, A. G., Amineva, S. P., and Palmenberg, A. C. (2003). Encephalomyocarditis viral protein 2A localizes to nucleoli and inhibits cap-dependent mRNA translation. Virus Research 95, 45-57.

An, J., Sun, Y., Sun, R., and Rettig, M. B. (2003). Kaposi's sarcoma-associated herpesvirus encoded vFLIP induces cellular IL-6 expression: the role of the NF-kappaB and JNK/AP1 pathways. Oncogene 22, 3371-3385.

Angeletti, B., Loster, J., Auricchio, A., Gekeler, F., Shinoda, K., Ballabio, A., Graw, J., and Marigo, V. (2003). An In Vivo Doxycycline-Controlled Expression System for Functional Studies of the Retina. Invest Ophthalmol Vis Sci 44, 755-760.

Arino, J., and Herrero, E. (2003). Use of tetracycline-regulatable promoters for functional analysis of protein phosphatases in yeast. Methods Enzymol 366, 347-358.

Arp, J., Kirchhof, M. G., Baroja, M. L., Nazarian, S. H., Chau, T. A., Strathdee, C. A., Ball, E. H., and Madrenas, J. (2003). Regulation of T-Cell Activation by Phosphodiesterase 4B2 Requires Its Dynamic Redistribution during Immunological Synapse Formation. Mol Cell Biol 23, 8042-8057.

Athman, R., Louvard, D., and Robine, S. (2003). Villin Enhances Hepatocyte Growth Factor-induced Actin Cytoskeleton Remodeling in Epithelial Cells. Mol Biol Cell 14, 4641-4653.

Atkinson, P. G. P., Coope, H. J., Rowe, M., and Ley, S. C. (2003). Latent Membrane Protein 1 of Epstein-Barr Virus Stimulates Processing of NF-{kappa}B2 p100 to p52. J Biol Chem 278, 51134-51142.

Aulehla, A., Wehrle, C., Brand-Saberi, B., Kemler, R., Gossler, A., Kanzler, B., and Herrmann, B. G. (2003). Wnt3a Plays a Major Role in the Segmentation Clock Controlling Somitogenesis. Developmental Cell 4, 395-406.

Auvinen, M., Jarvinen, K., Hotti, A., Okkeri, J., Laitinen, J., Janne, O. A., Coffino, P., Bergman, M., Andersson, L. C., Alitalo, K., and Holtta, E. (2003). Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc. The International Journal of Biochemistry & Cell Biology 35, 496-521.

Bachurski, C. J., Yang, G. H., Currier, T. A., Gronostajski, R. M., and Hong, D. (2003). Nuclear Factor I/Thyroid Transcription Factor 1 Interactions Modulate Surfactant Protein C Transcription. Mol Cell Biol 23, 9014-9024.

Baker, K. M., Wei, G., Schaffner, A. E., and Ostrowski, M. C. (2003). Ets-2 and Components of Mammalian SWI/SNF Form a Repressor Complex That Negatively Regulates the BRCA1 Promoter. J Biol Chem 278, 17876-17884.

Bakin, R. E., Gioeli, D., Bissonette, E. A., and Weber, M. J. (2003). Attenuation of Ras Signaling Restores Androgen Sensitivity to Hormone-refractory C4-2 Prostate Cancer Cells. Cancer Res 63, 1975-1980.

Baldin, V., Theis-Febvre, N., Benne, C., Froment, C., Cazales, M., Burlet-Schiltz, O., and Ducommun, B. (2003). PKB/Akt phosphorylates the CDC25B phosphatase and regulates its intracellular localisation. Biology of the Cell 95, 547-554.

Baluchamy, S., Rajabi, H. N., Thimmapaya, R., Navaraj, A., and Thimmapaya, B. (2003). Repression of c-Myc and inhibition of G1 exit in cells conditionally overexpressing p300 that is not dependent on its histone acetyltransferase activity. PNAS 100, 9524-9529.

Barlev, N. A., Emelyanov, A. V., Castagnino, P., Zegerman, P., Bannister, A. J., Sepulveda, M. A., Robert, F., Tora, L., Kouzarides, T., Birshtein, B. K., and Berger, S. L. (2003). A Novel Human Ada2 Homologue Functions with Gcn5 or Brg1 To Coactivate Transcription. Mol Cell Biol 23, 6944-6957.

Beauman, S. R., Campos, B., Kaetzel, M. A., and Dedman, J. R. (2003). CyclinB1 expression is elevated and mitosis is delayed in HeLa cells expressing autonomous CaMKII. Cellular Signalling 15, 1049-1057.

Becker, M. M., Peters, T. R., and Dermody, T. S. (2003). Reovirus {sigma}NS and {micro}NS Proteins Form Cytoplasmic Inclusion Structures in the Absence of Viral Infection. J Virol 77, 5948-5963.

Belgareh-Touze, N., Corral-Debrinski, M., Launhardt, H., Galan, J. M., Munder, T., Le Panse, S., and Haguenauer-Tsapis, R. (2003). Yeast functional analysis: identification of two essential genes involved in ER to Golgi trafficking. Traffic 4, 607-617.

Bellido, T., Ali, A. A., Plotkin, L. I., Fu, Q., Gubrij, I., Roberson, P. K., Weinstein, R. S., O'Brien, C. A., Manolagas, S. C., and Jilka, R. L. (2003). Proteasomal Degradation of Runx2 Shortens Parathyroid Hormone-induced Anti-apoptotic Signaling in Osteoblasts: A PUTATIVE EXPLANATION FOR WHY INTERMITTENT ADMINISTRATION IS NEEDED FOR BONE ANABOLISM. J Biol Chem 278, 50259-50272.

Ben-Yosef, T., Belyantseva, I. A., Saunders, T. L., Hughes, E. D., Kawamoto, K., Van Itallie, C. M., Beyer, L. A., Halsey, K., Gardner, D. J., Wilcox, E. R., et al. (2003). Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration. Hum Mol Genet 12, 2049-2061.

Berens, C., and Hillen, W. (2003). Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes. Eur J Biochem 270, 3109-3121.

Birger, Y., West, K. L., Postnikov, Y. V., Lim, J.-H., Furusawa, T., Wagner, J. P., Laufer, C. S., Kraemer, K. H., and Bustin, M. (2003). Chromosomal protein HMGN1 enhances the rate of DNA repair in chromatin. EMBO J 22, 1665-1675.

Biroccio, A., Amodei, S., Antonelli, A., Benassi, B., and Zupi, G. (2003). Inhibition of c-Myc Oncoprotein Limits the Growth of Human Melanoma Cells by Inducing Cellular Crisis. J Biol Chem 278, 35693-35701.

Biswas, R., Datta, S., Gupta, J. D., Novotny, M., Tebo, J., and Hamilton, T. A. (2003). Regulation of Chemokine mRNA Stability by Lipopolysaccharide and IL-10. J Immunol 170, 6202-6208.

Block, A., Puls, F., Muller, J., Milasinovic, D., Igelmann, D., Schafer, P., Kupfermann, N., Schmoldt, A., Ameis, D., and Greten, H. (2003). Highly suppressible expression of single-chain interleukin-12 by doxycycline following adenoviral infection with a single-vector Tet-regulatory system. J Gene Med 5, 190-200.

Bogengruber, E., Briza, P., Doppler, E., Wimmer, H., Koller, L., Fasiolo, F., Senger, B., Hegemann, J. H., and Breitenbach, M. (2003). Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes. FEMS Yeast Research 3, 35-43.

Bourdon, E., Kang, D.-K., Ghosh, M. C., Drake, S. K., Wey, J., Levine, R. L., and Rouault, T. A. (2003). The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2. Blood Cells, Molecules, and Diseases 31, 247-255.

Boya, P., Morales, M. C., Gonzalez-Polo, R. A., Andreau, K., Gourdier, I., Perfettini, J. L., Larochette, N., Deniaud, A., Baran-Marszak, F., Fagard, R., et al. (2003). The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family. Oncogene 22, 6220-6230.

Bozdayi, A. M., Uzunalimoglu, O., Turkyilmaz, A. R., Aslan, N., Sezgin, O., Sahin, T., Bozdayi, G., Cinar, K., Pai, S. B., Pai, R., et al. (2003). YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine. J Viral Hepat 10, 256-265.

Braudeau, C., Bouchet, D., Toquet, C., Tesson, L., Menoret, S., Iyer, S., Laboisse, C., Willis, D., Jarry, A., Buelow, R., et al. (2003). Generation of Heme Oxygenase-1-Transgenic Rats. Experimental Biology and Medicine 228, 466-1707.

Brem, R., Oroszlan-Szovik, K., Foser, S., Bohrmann, B., and Certa, U. (2003). Inhibition of proliferation by 1-8U in interferon-alpha-responsive and non-responsive cell lines. Cellular and Molecular Life Sciences 60, 1235-1248.

Brock, S. C., Goldenring, J. R., and Crowe, J. E., Jr. (2003). Apical recycling systems regulate directional budding of respiratory syncytial virus from polarized epithelial cells. PNAS 100, 15143-15148.

Bronte, V., Cingarlini, S., Apolloni, E., Serafini, P., Marigo, I., De Santo, C., Macino, B., Marin, O., and Zanovello, P. (2003). Effective Genetic Vaccination with a Widely Shared Endogenous Retroviral Tumor Antigen Requires CD40 Stimulation during Tumor Rejection Phase J Immunol 171, 6396-6405.

Brunner, C., Laumen, H., Nielsen, P. J., Kraut, N., and Wirth, T. (2003). Expression of the Aldehyde Dehydrogenase 2-like Gene Is Controlled by BOB.1/OBF.1 in B Lymphocytes. J Biol Chem 278, 45231-45239.

Buchholz, M., Biebl, A., Neesse, A., Wagner, M., Iwamura, T., Leder, G., Adler, G., and Gress, T. M. (2003). SERPINE2 (Protease Nexin I) Promotes Extracellular Matrix Production and Local Invasion of Pancreatic Tumors in Vivo. Cancer Res 63, 4945-4951.

Bulavin, D. V., Higashimoto, Y., Demidenko, Z. N., Meek, S., Graves, P., Phillips, C., Zhao, H., Moody, S. A., Appella, E., Piwnica-Worms, H., and Fornace, A. J., Jr. (2003). Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat Cell Biol 5, 545-551.

Calcagno, A. M., Bignell, E., Warn, P., Jones, M. D., Denning, D. W., Muhlschlegel, F. A., Rogers, T. R., and Haynes, K. (2003). Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation. Mol Microbiol 50, 1309-1318.

Camougrand, N., Grelaud-Coq, A., Marza, E., Priault, M., Bessoule, J. J., and Manon, S. (2003). The product of the UTH1 gene, required for Bax-induced cell death in yeast, is involved in the response to rapamycin. Mol Microbiol 47, 495-506.

Cannon, M., Philpott, N. J., and Cesarman, E. (2003). The Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Has Broad Signaling Effects in Primary Effusion Lymphoma Cells. J Virol 77, 57-67.

Cartier, A., Komai, T., and Masucci, M. G. (2003). The Us3 protein kinase of herpes simplex virus 1 blocks apoptosis and induces phosporylation of the Bcl-2 family member Bad. Experimental Cell Research 291, 242-250.

Cartier, A., Broberg, E., Komai, T., Henriksson, M., and Masucci, M. G. (2003). The herpes simplex virus-1 Us3 protein kinase blocks CD8T cell lysis by preventing the cleavage of Bid by granzyme B. Cell Death Differ 10, 1320-1328.

Carvalhal, A. V., Marcelino, I., and Carrondo, M. J. T. (2003). Metabolic changes during cell growth inhibition by p27 overexpression. Applied Microbiology and Biotechnology 63, 164-173.

Cataisson, C., Joseloff, E., Murillas, R., Wang, A., Atwell, C., Torgerson, S., Gerdes, M., Subleski, J., Gao, J.-L., Murphy, P. M., et al. (2003). Activation of Cutaneous Protein Kinase C{alpha} Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways. J Immunol 171, 2703-2713.

Cattan, P., Rottembourg, D., Cottet, S., Tardivel, I., Dupraz, P., Thorens, B., Boitard, C., and Carel, J. C. (2003). Destruction of conditional insulinoma cell lines in NOD mice: a role for autoimmunity. Diabetologia 46, 504-510. Epub 2003 Mar 2025.

Cejka, P., Stojic, L., Mojas, N., Russell, A. M., Heinimann, K., Cannavo, E., di Pietro, M., Marra, G., and Jiricny, J. (2003). Methylation-induced G2/M arrest requires a full complement of the mismatch repair protein hMLH1. EMBO J 22, 2245-2254.

Cejka, P., Marra, G., Hemmerle, C., Cannavo, E., Storchova, Z., and Jiricny, J. (2003). Differential Killing of Mismatch Repair-Deficient and -Proficient Cells: Towards the Therapy of Tumors with Microsatellite Instability. Cancer Res 63, 8113-8117.

Chambers, I., Colby, D., Robertson, M., Nichols, J., Lee, S., Tweedie, S., and Smith, A. (2003). Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells. Cell 113, 643-655.

Chang, Y., Tesco, G., Jeong, W. J., Lindsley, L., Eckman, E. A., Eckman, C. B., Tanzi, R. E., and Guenette, S. Y. (2003). Generation of the {beta}-Amyloid Peptide and the Amyloid Precursor Protein C-terminal Fragment {gamma} Are Potentiated by FE65L1. J Biol Chem 278, 51100-51107.

Chen, X., Kandasamy, K., and Srivastava, R. K. (2003). Differential Roles of RelA (p65) and c-Rel Subunits of Nuclear Factor {kappa}B in Tumor Necrosis Factor-related Apoptosis-inducing Ligand Signaling. Cancer Res 63, 1059-1066.

Chen, C.-Y. A., and Shyu, A.-B. (2003). Rapid Deadenylation Triggered by a Nonsense Codon Precedes Decay of the RNA Body in a Mammalian Cytoplasmic Nonsense-Mediated Decay Pathway. Mol Cell Biol 23, 4805-4813.

Chen, Z., and Manley, J. L. (2003). Core Promoter Elements and TAFs Contribute to the Diversity of Transcriptional Activation in Vertebrates. Mol Cell Biol 23, 7350-7362.

Chen, A., Muzzio, I. A., Malleret, G., Bartsch, D., Verbitsky, M., Pavlidis, P., Yonan, A. L., Vronskaya, S., Grody, M. B., and Cepeda, I. (2003). Inducible Enhancement of Memory Storage and Synaptic Plasticity in Transgenic Mice Expressing an Inhibitor of ATF4 (CREB-2) and C/EBP Proteins. Neuron 39, 655-669.

Chen, Z., and Manley, J. L. (2003). In Vivo Functional Analysis of the Histone 3-like TAF9 and a TAF9-related Factor, TAF9L. J Biol Chem 278, 35172-35183.

Chen, Y., Stamatoyannopoulos, G., and Song, C. Z. (2003). Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. Cancer Res 63, 4801-4804.

Cheng, G., Yang, K., and He, B. (2003). Dephosphorylation of eIF-2{alpha} Mediated by the {gamma}134.5 Protein of Herpes Simplex Virus Type 1 Is Required for Viral Response to Interferon but Is Not Sufficient for Efficient Viral Replication. J Virol 77, 10154-10161.

Cheutin, T., McNairn, A. J., Jenuwein, T., Gilbert, D. M., Singh, P. B., and Misteli, T. (2003). Maintenance of Stable Heterochromatin Domains by Dynamic HP1 Binding. Science 299, 721-725.

Chevalier, M. S., and Johnson, D. C. (2003). Human Cytomegalovirus US3 Chimeras Containing US2 Cytosolic Residues Acquire Major Histocompatibility Class I and II Protein Degradation Properties. J Virol 77, 4731-4738.

Chiang, Y.-C., Teng, S.-C., Su, Y.-N., Hsieh, F.-J., and Wu, K.-J. (2003). c-Myc Directly Regulates the Transcription of the NBS1 Gene Involved in DNA Double-strand Break Repair J Biol Chem 278, 19286-19291.

Chiba, H., Gotoh, T., Kojima, T., Satohisa, S., Kikuchi, K., Osanai, M., and Sawada, N. (2003). Hepatocyte nuclear factor (HNF)-4[alpha] triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells. Experimental Cell Research 286, 288-297.

Chow, J. P. H., Siu, W. Y., Ho, H. T. B., Ma, K. H. T., Ho, C. C., and Poon, R. Y. C. (2003). Differential Contribution of Inhibitory Phosphorylation of CDC2 and CDK2 for Unperturbed Cell Cycle Control and DNA Integrity Checkpoints. J Biol Chem 278, 40815-40828.

Chtarto, A., Tenenbaum, L., Velu, T., Brotchi, J., Levivier, M., and Blum, D. (2003). Minocycline-induced activation of tetracycline-responsive promoter. Neuroscience Letters 352, 155-158.

Chun, S. J., Rasband, M. N., Sidman, R. L., Habib, A. A., and Vartanian, T. (2003). Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination. J Cell Biol 163, 397-408.

Chyung, J. H., and Selkoe, D. J. (2003). Inhibition of Receptor-mediated Endocytosis Demonstrates Generation of Amyloid {beta}-Protein at the Cell Surface. J Biol Chem 278, 51035-51043.

Cobbs, C. S., Whisenhunt, T. R., Wesemann, D. R., Harkins, L. E., Van Meir, E. G., and Samanta, M. (2003). Inactivation of Wild-Type p53 Protein Function by Reactive Oxygen and Nitrogen Species in Malignant Glioma Cells. Cancer Res 63, 8670-8673.

Cohen, D., and Musch, A. (2003). Apical surface formation in MDCK cells: regulation by the serine/threonine kinase EMK1. Methods 30, 269-276.

Colby, C. R., Whisler, K., Steffen, C., Nestler, E. J., and Self, D. W. (2003). Striatal Cell Type-Specific Overexpression of Delta FosB Enhances Incentive for Cocaine. J Neurosci 23, 2488-2493.

Colegio, O. R., Itallie, C. V., Rahner, C., and Anderson, J. M. (2003). Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am J Physiol Cell Physiol 284, C1346-1354.

Cong, F., Zhang, J., Pao, W., Zhou, P., and Varmus, H. (2003). A protein knockdown strategy to study the function of beta-catenin in tumorigenesis. BMC Mol Biol 4, 10.

Conner, S. D., and Schmid, S. L. (2003). Differential requirements for AP-2 in clathrin-mediated endocytosis. J Cell Biol 162, 773-780.

Coppo, P., Dusanter-Fourt, I., Millot, G., Nogueira, M. M., Dugray, A., Bonnet, M. L., Mitjavila-Garcia, M. T., Le Pesteur, D., Guilhot, F., Vainchenker, W., et al. (2003). Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells. Oncogene 22, 4102-4110.

Cortellino, S., Turner, D., Masciullo, V., Schepis, F., Albino, D., Daniel, R., Skalka, A. M., Meropol, N. J., Alberti, C., Larue, L., and Bellacosa, A. (2003). From The Cover: The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity. PNAS 100, 15071-15076.

Cowell, L. G., Davila, M., Yang, K., Kepler, T. B., and Kelsoe, G. (2003). Prospective Estimation of Recombination Signal Efficiency and Identification of Functional Cryptic Signals in the Genome by Statistical Modeling. J Exp Med 197, 207-220.

Cozzi, A., Levi, S., Corsi, B., Santambrogio, P., Campanella, A., Gerardi, G., and Arosio, P. (2003). Role of iron and ferritin in TNF[alpha]-induced apoptosis in HeLa cells. FEBS Letters 537, 187-192.

Crescenzi, E., Palumbo, G., and Brady, H. J. (2003). Bcl-2 activates a programme of premature senescence in human carcinoma cells. Biochem J 375, 263-274.

Crighton, D., Woiwode, A., Zhang, C., Mandavia, N., Morton, J. P., Warnock, L. J., Milner, J., White, R. J., and Johnson, D. L. (2003). p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB. EMBO J 22, 2810-2820.

Crump, C. M., Hung, C.-H., Thomas, L., Wan, L., and Thomas, G. (2003). Role of PACS-1 in Trafficking of Human Cytomegalovirus Glycoprotein B and Virus Production. J Virol 77, 11105-11113.

Cruz, J. C., Tseng, H.-C., Goldman, J. A., Shih, H., and Tsai, L.-H. (2003). Aberrant Cdk5 Activation by p25 Triggers Pathological Events Leading to Neurodegeneration and Neurofibrillary Tangles. Neuron 40, 471-483.

Cui, C.-Y., Durmowicz, M., Ottolenghi, C., Hashimoto, T., Griggs, B., Srivastava, A. K., and Schlessinger, D. (2003). Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles. Hum Mol Genet, ddg325.

Cunningham, M. A., Pipe, S. W., Zhang, B., Hauri, H. P., Ginsburg, D., and Kaufman, R. J. (2003). LMAN1 is a molecular chaperone for the secretion of coagulation factor VIII. J Thromb Haemost 1, 2360-2367.

Curnock, A. P., Sotsios, Y., Wright, K. L., and Ward, S. G. (2003). Optimal Chemotactic Responses of Leukemic T Cells to Stromal Cell-Derived Factor-1 Requires the Activation of Both Class IA and IB Phosphoinositide 3-Kinases. J Immunol 170, 4021-3014.

Curnock, A. P., and Ward, S. G. (2003). Development and characterisation of tetracycline-regulated phosphoinositide 3-kinase mutants: assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling. Journal of Immunological Methods 273, 29-41.

Czubryt, M. P., McAnally, J., Fishman, G. I., and Olson, E. N. (2003). Regulation of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha ) and mitochondrial function by MEF2 and HDAC5. PNAS 100, 1711-1716.

D'Silva, P. D., Schilke, B., Walter, W., Andrew, A., and Craig, E. A. (2003). J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. PNAS 100, 13839-13844.

Dai, Y., Datta, S., Novotny, M., and Hamilton, T. A. (2003). TGF{beta} inhibits LPS-induced chemokine mRNA stabilization. Blood 102, 1178-1185.

Daniel, R., Kao, G., Taganov, K., Greger, J. G., Favorova, O., Merkel, G., Yen, T. J., Katz, R. A., and Skalka, A. M. (2003). Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response. PNAS 100, 4778-4783.

Darios, F., Corti, O., Lucking, C. B., Hampe, C., Muriel, M.-P., Abbas, N., Gu, W.-J., Hirsch, E. C., Rooney, T., Ruberg, M., and Brice, A. (2003). Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death. Hum Mol Genet 12, 517-2493.

Davis, B. B., Dong, Y., and Weiss, R. H. (2003). Overexpression of p73 causes apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol 284, C16-23.

de la Cueva-Mendez, G., Mills, A. D., Clay-Farrace, L., Diaz-Orejas, R., and Laskey, R. A. (2003). Regulatable killing of eukaryotic cells by the prokaryotic proteins Kid and Kis. EMBO J 22, 246-251.

Dean, J. L. E., Sarsfield, S. J., Tsounakou, E., and Saklatvala, J. (2003). p38 Mitogen-activated Protein Kinase Stabilizes mRNAs That Contain Cyclooxygenase-2 and Tumor Necrosis Factor AU-rich Elements by Inhibiting Deadenylation. J Biol Chem 278, 39470-39476.

Debure, L., Vayssiere, J.-L., Rincheval, V., Loison, F., Le Drean, Y., and Michel, D. (2003). Intracellular clusterin causes juxtanuclear aggregate formation and mitochondrial alteration. J Cell Sci 116, 3109-3121.

Dekker, S., Toussaint, W., Panayotou, G., de Wit, T., Visser, P., Grosveld, F., and Drabek, D. (2003). Intracellularly Expressed Single-Domain Antibody against p15 Matrix Protein Prevents the Production of Porcine Retroviruses. J Virol 77, 12132-12139.

Deutsch, E., Jarrousse, S., Buet, D., Dugray, A., Bonnet, M.-L., Vozenin-Brotons, M.-C., Guilhot, F., Turhan, A. G., Feunteun, J., and Bourhis, J. (2003). Down-regulation of BRCA1 in BCR-ABL-expressing hematopoietic cells. Blood 101, 4583-4588.

di Pietro, M., Marra, G., Cejka, P., Stojic, L., Menigatti, M., Cattaruzza, M. S., and Jiricny, J. (2003). Mismatch Repair-Dependent Transcriptome Changes In Human Cells Treated with the Methylating Agent N-Methyl-N'-Nitro-N-Nitrosoguanidine. Cancer Res 63, 8158-8166.

Dihne, M., Bernreuther, C., Sibbe, M., Paulus, W., and Schachner, M. (2003). A New Role for the Cell Adhesion Molecule L1 in Neural Precursor Cell Proliferation, Differentiation, and Transmitter-Specific Subtype Generation. J Neurosci 23, 6638-6650.

Dohn, M., Nozell, S., Willis, A., and Chen, X. (2003). Tumor suppressor gene-inducible cell lines. Methods Mol Biol 223, 221-235.

Doi, T., Kinoshita, K., Ikegawa, M., Muramatsu, M., and Honjo, T. (2003). Inaugural Article: De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination. PNAS 100, 2634-2638.

Dressel, R., Grzeszik, C., Kreiss, M., Lindemann, D., Herrmann, T., Walter, L., and Gunther, E. (2003). Differential Effect of Acute and Permanent Heat Shock Protein 70 Overexpression in Tumor Cells on Lysability by Cytotoxic T Lymphocytes. Cancer Res 63, 8212-8220.

Drexler, H. C., and Pebler, S. (2003). Inducible p27(Kip1) expression inhibits proliferation of K562 cells and protects against apoptosis induction by proteasome inhibitors. Cell Death Differ 10, 290-301.

Duvezin-Caubet, S., Caron, M., Giraud, M.-F., Velours, J., and di Rago, J.-P. (2003). The two rotor components of yeast mitochondrial ATP synthase are mechanically coupled by subunit {delta}. PNAS 100, 13235-13240.

Eberle, J., Fecker, L. F., Hossini, A. M., Wieder, T., Daniel, P. T., Orfanos, C. E., and Geilen, C. C. (2003). CD95/Fas signaling in human melanoma cells: conditional expression of CD95L/FasL overcomes the intrinsic apoptosis resistance of malignant melanoma and inhibits growth and progression of human melanoma xenotransplants. Oncogene 22, 9131-9141.

Edelstein, L. C., Lagos, L., Simmons, M., Tirumalai, H., and Gelinas, C. (2003). NF-{kappa}B-Dependent Assembly of an Enhanceosome-Like Complex on the Promoter Region of Apoptosis Inhibitor Bfl-1/A1. Mol Cell Biol 23, 2749-2761.

Edwardson, J. M., Wang, C.-T., Gong, B., Wyttenbach, A., Bai, J., Jackson, M. B., Chapman, E. R., and Morton, A. J. (2003). Expression of Mutant Huntingtin Blocks Exocytosis in PC12 Cells by Depletion of Complexin II. J Biol Chem 278, 30849-30853.

Elias, J. A., Zheng, T., Lee, C. G., Homer, R. J., Chen, Q., Ma, B., Blackburn, M., and Zhu, Z. (2003). Transgenic Modeling of Interleukin-13 in the Lung. Chest 123, 339S-a-2493.

Eliopoulos, A. G., Waites, E. R., Blake, S. M. S., Davies, C., Murray, P., and Young, L. S. (2003). TRAF1 Is a Critical Regulator of JNK Signaling by the TRAF-Binding Domain of the Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1 but Not CD40. J Virol 77, 1316-1328.

Elsasser, A., Franzen, M., Kohlmann, A., Weisser, M., Schnittger, S., Schoch, C., Reddy, V. A., Burel, S., Zhang, D. E., Ueffing, M., et al. (2003). The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner. Oncogene 22, 5646-5657.

Eymin, B., Leduc, C., Coll, J. L., Brambilla, E., and Gazzeri, S. (2003). p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice. Oncogene 22, 1822-1835.

Faraci, E., Eck, M., Gerstmayer, B., Bosio, A., and Vogel, W. F. (2003). An extracellular matrix-specific microarray allowed the identification of target genes downstream of discoidin domain receptors. Matrix Biology 22, 373-381.

Fechner, H., Wang, X., Srour, M., Siemetzki, U., Seltmann, H., Sutter, A. P., Scherubl, H., Zouboulis, C. C., Schwaab, R., Hillen, W., et al. (2003). A novel tetracycline-controlled transactivator-transrepressor system enables external control of oncolytic adenovirus replication. Gene Ther 10, 1680-1690.

Fernandez, P. C., Frank, S. R., Wang, L., Schroeder, M., Liu, S., Greene, J., Cocito, A., and Amati, B. (2003). Genomic targets of the human c-Myc protein. Genes Dev 17, 1115-1129.

Feuermann, M., Francisci, S., Rinaldi, T., De Luca, C., Rohou, H., Frontali, L., and Bolotin-Fukuhara, M. (2003). The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu. EMBO Reports 4, 53-58.

Filleur, S., Courtin, A., Ait-Si-Ali, S., Guglielmi, J., Merle, C., Harel-Bellan, A., Clezardin, P., and Cabon, F. (2003). SiRNA-mediated Inhibition of Vascular Endothelial Growth Factor Severely Limits Tumor Resistance to Antiangiogenic Thrombospondin-1 and Slows Tumor Vascularization and Growth. Cancer Res 63, 3919-3922.

Fitch, M. E., Cross, I. V., Turner, S. J., Adimoolam, S., Lin, C. X., Williams, K. G., and Ford, J. M. (2003). The DDB2 nucleotide excision repair gene product p48 enhances global genomic repair in p53 deficient human fibroblasts. DNA Repair 2, 819-826.

Folliot, S., Briot, D., Conrath, H., Provost, N., Cherel, Y., Moullier, P., and Rolling, F. (2003). Sustained tetracycline-regulated transgene expression in vivo in rat retinal ganglion cells using a single type 2 adeno-associated viral vector. J Gene Med 5, 493-501.

Fornaro, M., Plescia, J., Chheang, S., Tallini, G., Zhu, Y.-M., King, M., Altieri, D. C., and Languino, L. R. (2003). Fibronectin Protects Prostate Cancer Cells from Tumor Necrosis Factor-{alpha}-induced Apoptosis via the AKT/Survivin Pathway. J Biol Chem 278, 50402-50411.

Fortugno, P., Beltrami, E., Plescia, J., Fontana, J., Pradhan, D., Marchisio, P. C., Sessa, W. C., and Altieri, D. C. (2003). Regulation of survivin function by Hsp90. PNAS 100, 13791-13796.

Franchitto, A., Oshima, J., and Pichierri, P. (2003). The G2-phase Decatenation Checkpoint Is Defective in Werner Syndrome Cells Cancer Res 63, 3289-3295.

Frank, S. R., Parisi, T., Taubert, S., Fernandez, P., Fuchs, M., Chan, H.-M., Livingston, D. M., and Amati, B. (2003). MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Reports 4, 575-580.

Fridmacher, V., Kaltschmidt, B., Goudeau, B., Ndiaye, D., Rossi, F. M., Pfeiffer, J., Kaltschmidt, C., Israel, A., and Memet, S. (2003). Forebrain-Specific Neuronal Inhibition of Nuclear Factor-{kappa}B Activity Leads to Loss of Neuroprotection. J Neurosci 23, 9403-9408.

Friedrichsen, B. N., Richter, H. E., Hansen, J. A., Rhodes, C. J., Nielsen, J. H., Billestrup, N., and Moldrup, A. (2003). Signal Transducer and Activator of Transcription 5 Activation Is Sufficient to Drive Transcriptional Induction of Cyclin D2 Gene and Proliferation of Rat Pancreatic {beta}-Cells. Mol Endocrinol 17, 945-1707.

Fruci, D., Lauvau, G., Saveanu, L., Amicosante, M., Butler, R. H., Polack, A., Ginhoux, F., Lemonnier, F., Firat, H., and van Endert, P. M. (2003). Quantifying Recruitment of Cytosolic Peptides for HLA Class I Presentation: Impact of TAP Transport. J Immunol 170, 2977-3014.

Fukazawa, T., Walter, B., and Owen-Schaub, L. B. (2003). Adenoviral Bid Overexpression Induces Caspase-dependent Cleavage of Truncated Bid and p53-independent Apoptosis in Human Non-small Cell Lung Cancers. J Biol Chem 278, 25428-25434.

Fuks, F., Hurd, P. J., Wolf, D., Nan, X., Bird, A. P., and Kouzarides, T. (2003). The Methyl-CpG-binding Protein MeCP2 Links DNA Methylation to Histone Methylation. J Biol Chem 278, 4035-4040.

Furuta, T., Takemura, H., Liao, Z.-Y., Aune, G. J., Redon, C., Sedelnikova, O. A., Pilch, D. R., Rogakou, E. P., Celeste, A., Chen, H. T., et al. (2003). Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes. J Biol Chem 278, 20303-20312.

Fux, C., and Fussenegger, M. (2003). Toward higher order control modalities in mammalian cells-independent adjustment of two different gene activities. Biotechnol Prog 19, 109-120.

Gabriel, B., Sureau, F., Casselyn, M., Teissie, J., and Petit, P. X. (2003). Retroactive pathway involving mitochondria in electroloaded cytochrome c-induced apoptosis : Protective properties of Bcl-2 and Bcl-XL. Experimental Cell Research 289, 195-210.

Gagnon, C. A., Lachapelle, G., Langelier, Y., Massie, B., and Dea, S. (2003). Adenoviral-expressed GP5 of porcine respiratory and reproductive syndrome virus differs in its cellular maturation from the authentic viral protein but maintains known biological functions. Arch Virol 148, 951-972.

Gallagher, A. R., Schonig, K., Brown, N., Bujard, H., and Witzgall, R. (2003). Use of the tetracycline system for inducible protein synthesis in the kidney. J Am Soc Nephrol 14, 2042-2051.

Garcia-Gimeno, M. A., Munoz, I., Arino, J., and Sanz, P. (2003). Molecular Characterization of Ypi1, a Novel Saccharomyces cerevisiae Type 1 Protein Phosphatase Inhibitor. J Biol Chem 278, 47744-47752.

Garcia-Rubio, M., Huertas, P., Gonzalez-Barrera, S., and Aguilera, A. (2003). Recombinogenic Effects of DNA-Damaging Agents Are Synergistically Increased by Transcription in Saccharomyces cerevisiae: New Insights Into Transcription-Associated Recombination. Genetics 165, 457-466.

Geib, T., Sauder, C., Venturelli, S., Hassler, C., Staeheli, P., and Schwemmle, M. (2003). Selective Virus Resistance Conferred by Expression of Borna Disease Virus Nucleocapsid Components. J Virol 77, 4283-4290.

Giavazzi, R., Sennino, B., Coltrini, D., Garofalo, A., Dossi, R., Ronca, R., Tosatti, M. P., and Presta, M. (2003). Distinct role of fibroblast growth factor-2 and vascular endothelial growth factor on tumor growth and angiogenesis. Am J Pathol 162, 1913-1926.

Gillissen, B., Essmann, F., Graupner, V., Starck, L., Radetzki, S., Dorken, B., Schulze-Osthoff, K., and Daniel, P. T. (2003). Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. EMBO J 22, 3580-3590.

Ginn-Pease, M. E., and Eng, C. (2003). Increased Nuclear Phosphatase and Tensin Homologue Deleted on Chromosome 10 Is Associated with G0-G1 in MCF-7 Cells. Cancer Res 63, 282-286.

Giuliano, P., de Cristofaro, T., Affaitati, A., Pizzulo, G. M., Feliciello, A., Criscuolo, C., De Michele, G., Filla, A., Avvedimento, E. V., and Varrone, S. (2003). DNA damage induced by polyglutamine-expanded proteins. Hum Mol Genet 12, 2301-2309.

Gober, M. D., Smith, C. C., Ueda, K., Toretsky, J. A., and Aurelian, L. (2003). Forced Expression of the H11 Heat Shock Protein Can Be Regulated by DNA Methylation and Trigger Apoptosis in Human Cells. J Biol Chem 278, 37600-37609.

Gohda, J., Nomura, Y., Suzuki, H., Arai, H., Akiyama, T., and Inoue, J. (2003). Elimination of the vertebrate Escherichia coli Ras-like protein homologue leads to cell cycle arrest at G1 phase and apoptosis. Oncogene 22, 1340-1348.

Goloudina, A., Yamaguchi, H., Chervyakova, D. B., Appella, E., Fornace, A. J., Jr., and Bulavin, D. V. (2003). Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint. Cell Cycle 2, 473-478.

Gorgoulis, V. G., Zacharatos, P., Kotsinas, A., Kletsas, D., Mariatos, G., Zoumpourlis, V., Ryan, K. M., Kittas, C., and Papavassiliou, A. G. (2003). p53 activates ICAM-1 (CD54) expression in an NF-{kappa}B-independent manner. EMBO J 22, 1567-1578.

Grandori, C., Wu, K.-J., Fernandez, P., Ngouenet, C., Grim, J., Clurman, B. E., Moser, M. J., Oshima, J., Russell, D. W., Swisshelm, K., et al. (2003). Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev 17, 1569-1574.

Green, E. A., Gorelik, L., McGregor, C. M., Tran, E. H., and Flavell, R. A. (2003). CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-{beta}-TGF-{beta} receptor interactions in type 1 diabetes. PNAS 100, 10878-10883.

Greenberg, C. C., Meredith, K. N., Yan, L., and Brady, M. J. (2003). Protein Targeting to Glycogen Overexpression Results in the Specific Enhancement of Glycogen Storage in 3T3-L1 Adipocytes. J Biol Chem 278, 30835-30842.

Grill, M. A., Bales, M. A., Fought, A. N., Rosburg, K. C., Munger, S. J., and Antin, P. B. (2003). Tetracycline-inducible system for regulation of skeletal muscle-specific gene expression in transgenic mice. Transgenic Res 12, 33-43.

Gros, R., Afroze, T., You, X.-M., Kabir, G., Van Wert, R., Kalair, W., Hoque, A. E., Mungrue, I. N., and Husain, M. (2003). Plasma Membrane Calcium ATPase Overexpression in Arterial Smooth Muscle Increases Vasomotor Responsiveness and Blood Pressure. Circ Res 93, 614-621.

Gross, I., Morrison, D. J., Hyink, D. P., Georgas, K., English, M. A., Mericskay, M., Hosono, S., Sassoon, D., Wilson, P. D., Little, M., and Licht, J. D. (2003). The Receptor Tyrosine Kinase Regulator Sprouty1 Is a Target of the Tumor Suppressor WT1 and Important for Kidney Development. J Biol Chem 278, 41420-41430.

Groth, A., Lukas, J., Nigg, E. A., Sillje, H. H. W., Wernstedt, C., Bartek, J., and Hansen, K. (2003). Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J 22, 1676-1687.

Gryz, E. A., and Meakin, S. O. (2003). Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-dependent, but not nerve growth factor-independent, differentiation and cell cycle arrest in the human neuroblastoma cell line, SY5Y. Oncogene 22, 8774-8785.

Gu, H., and Schoenberg, D. R. (2003). U2AF modulates poly(A) length control by the poly(A)-limiting element. Nucl Acids Res 31, 6264-6271.

Guan, F., Palacios, D., Hussein, R. I., and Gunderson, S. I. (2003). Determinants within an 18-Amino-Acid U1A Autoregulatory Domain That Uncouple Cooperative RNA Binding, Inhibition of Polyadenylation, and Homodimerization. Mol Cell Biol 23, 3163-3172.

Gunther, E. J., Moody, S. E., Belka, G. K., Hahn, K. T., Innocent, N., Dugan, K. D., Cardiff, R. D., and Chodosh, L. A. (2003). Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. Genes Dev 17, 488-501.

Guo, J.-T., Pryce, M., Wang, X., Barrasa, M. I., Hu, J., and Seeger, C. (2003). Conditional Replication of Duck Hepatitis B Virus in Hepatoma Cells. J Virol 77, 1885-1893.

Guo, G., Yan-Sanders, Y., Lyn-Cook, B. D., Wang, T., Tamae, D., Ogi, J., Khaletskiy, A., Li, Z., Weydert, C., Longmate, J. A., et al. (2003). Manganese Superoxide Dismutase-Mediated Gene Expression in Radiation-Induced Adaptive Responses. Mol Cell Biol 23, 2362-2378.

Guo, Z., Su, W., Ma, Z., Smith, G. M., and Gong, M. C. (2003). Ca2+-independent Phospholipase A2 Is Required for Agonist-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle. J Biol Chem 278, 1856-1863.

Haberman, R. P., Samulski, R. J., and McCown, T. J. (2003). Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion. Nat Med 9, 1076-1080.

Haigis, M. C., and Raines, R. T. (2003). Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway. J Cell Sci 116, 313-324.

Hall, A. B., Jura, N., DaSilva, J., Jang, Y. J., Gong, D., and Bar-Sagi, D. (2003). hSpry2 Is Targeted to the Ubiquitin-Dependent Proteasome Pathway by c-Cbl. Current Biology 13, 308-314.

Hamilton, B. J., Genin, A., Cron, R. Q., and Rigby, W. F. C. (2003). Delineation of a Novel Pathway That Regulates CD154 (CD40 Ligand) Expression. Mol Cell Biol 23, 510-525.

Hammond, D. E., Carter, S., McCullough, J., Urbe, S., Vande Woude, G., and Clague, M. J. (2003). Endosomal Dynamics of Met Determine Signaling Output. Mol Biol Cell 14, 1346-1354.

Hammond, E. M., Dorie, M. J., and Giaccia, A. J. (2003). ATR/ATM Targets Are Phosphorylated by ATR in Response to Hypoxia and ATM in Response to Reoxygenation. J Biol Chem 278, 12207-12213.

Hardie, W. D., Le Cras, T. D., Jiang, K., Tichelaar, J. W., Azhar, M., and Korfhagen, T. R. (2003). Conditional Expression of Transforming Growth Factor-{alpha} in Adult Mouse Lung Causes Pulmonary Fibrosis. Am J Physiol Lung Cell Mol Physiol, 00208.02003.

Hari, M., Wang, Y., Veeraraghavan, S., and Cabral, F. (2003). Mutations in {alpha}- and {beta}-Tubulin That Stabilize Microtubules and Confer Resistance to Colcemid and Vinblastine. Mol Cancer Ther 2, 597-605.

Hari, M., Yang, H., Zeng, C., Canizales, M., and Cabral, F. (2003). Expression of class III beta-tubulin reduces microtubule assembly and confers resistance to paclitaxel. Cell Motil Cytoskeleton 56, 45-56.

Haribhai, D., Engle, D., Meyer, M., Donermeyer, D., White, J. M., and Williams, C. B. (2003). A Threshold for Central T Cell Tolerance to an Inducible Serum Protein. J Immunol 170, 3007-3014.

Hayakawa, M., Miyashita, H., Sakamoto, I., Kitagawa, M., Tanaka, H., Yasuda, H., Karin, M., and Kikugawa, K. (2003). Evidence that reactive oxygen species do not mediate NF-{kappa}B activation. EMBO J 22, 3356-3366.

He, B., Raab-Traub, N., Casali, P., and Cerutti, A. (2003). EBV-Encoded Latent Membrane Protein 1 Cooperates with BAFF/BLyS and APRIL to Induce T Cell-Independent Ig Heavy Chain Class Switching J Immunol 171, 5215-5224.

Hedou, G., and Mansuy, I. M. (2003). Inducible molecular switches for the study of long-term potentiation. Philos Trans R Soc Lond B Biol Sci 358, 797-804.

Hegde, N. R., and Johnson, D. C. (2003). Human Cytomegalovirus US2 Causes Similar Effects on Both Major Histocompatibility Complex Class I and II Proteins in Epithelial and Glial Cells. J Virol 77, 9287-9294.

Helt, C. E., Staversky, R. J., Lee, Y.-J., Bambara, R. A., Keng, P. C., and O'Reilly, M. A. (2003). The CDK and PCNA domains on p21 Cip1 both function to inhibit G1/S progression during hyperoxia. Am J Physiol Lung Cell Mol Physiol, 00243.02003.

Hennemann, H., Vassen, L., Geisen, C., Eilers, M., and Moroy, T. (2003). Identification of a Novel Kruppel-associated Box Domain Protein, Krim-1, That Interacts with c-Myc and Inhibits Its Oncogenic Activity. J Biol Chem 278, 28799-28811.

Hermanson, E., Joseph, B., Castro, D., Lindqvist, E., Aarnisalo, P., Wallen, A., Benoit, G., Hengerer, B., Olson, L., and Perlmann, T. (2003). Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells. Experimental Cell Research 288, 324-334.

Herrera, G. M., Pozo, M. J., Zvara, P., Petkov, G. V., Bond, C. T., Adelman, J. P., and Nelson, M. T. (2003). Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel. J Physiol 551, 893-903.

Hersberger, M., Patarroyo-White, S., Qian, X., Arnold, K. S., Rohrer, L., Balestra, M. E., and Innerarity, T. L. (2003). Regulatable liver expression of the rabbit apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1 (APOBEC-1) in mice lacking endogenous APOBEC-1 leads to aberrant hyperediting. Biochem J 369, 255-262.

Herzig, M. C. S., Trevino, A. V., Liang, H., Salinas, R., Waters, S. J., MacDonald, J. R., Woynarowska, B. A., and Woynarowski, J. M. (2003). Apoptosis induction by the dual-action DNA- and protein-reactive antitumor drug irofulven is largely Bcl-2-independent. Biochemical Pharmacology 65, 503-513.

Hilleren, P. J., and Parker, R. (2003). Cytoplasmic Degradation of Splice-Defective Pre-mRNAs and Intermediates. Molecular Cell 12, 1453-1465.

Hitoshi, Y., Gururaja, T., Pearsall, D. M., Lang, W., Sharma, P., Huang, B., Catalano, S. M., McLaughlin, J., Pali, E., and Peelle, B. (2003). Cellular Localization and Antiproliferative Effect of Peptides Discovered from a Functional Screen of a Retrovirally Delivered Random Peptide Library. Chemistry & Biology 10, 975-987.

Hoffmann, A., Ciani, E., Boeckardt, J., Holsboer, F., Journot, L., and Spengler, D. (2003). Transcriptional Activities of the Zinc Finger Protein Zac Are Differentially Controlled by DNA Binding. Mol Cell Biol 23, 988-1003.

Hokuto, I., Perl, A.-K. T., and Whitsett, J. A. (2003). Prenatal, but Not Postnatal, Inhibition of Fibroblast Growth Factor Receptor Signaling Causes Emphysema. J Biol Chem 278, 415-421.

Hokuto, I., Perl, A.-K. T., and Whitsett, J. A. (2003). FGF-SIGNALING IS REQUIRED FOR PULMONARY HOMEOSTASIS FOLLOWING HYPEROXIA. Am J Physiol Lung Cell Mol Physiol, 00278.02003.

Hong, Y. H., Varanasi, U. S., Yang, W., and Leff, T. (2003). AMP-activated Protein Kinase Regulates HNF4{alpha} Transcriptional Activity by Inhibiting Dimer Formation and Decreasing Protein Stability. J Biol Chem 278, 27495-27501.

Hope, A. D., de Silva, R., Fischer, D. F., Hol, E. M., van Leeuwen, F. W., and Lees, A. J. (2003). Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression. J Neurochem 86, 394-404.

Hori, T., Haraguchi, T., Hiraoka, Y., Kimura, H., and Fukagawa, T. (2003). Dynamic behavior of Nuf2-Hec1 complex that localizes to the centrosome and centromere and is essential for mitotic progression in vertebrate cells. J Cell Sci 116, 3347-3362.

Horn, C., Offen, N., Nystedt, S., Hacker, U., and Wimmer, E. A. (2003). piggyBac-Based Insertional Mutagenesis and Enhancer Detection as a Tool for Functional Insect Genomics. Genetics 163, 647-760.

Horn, C., and Wimmer, E. A. (2003). A transgene-based, embryo-specific lethality system for insect pest management. Nat Biotechnol 21, 64-70.

Hossini, A. M., Eberle, J., Fecker, L. F., Orfanos, C. E., and Geilen, C. C. (2003). Conditional expression of exogenous Bcl-XS triggers apoptosis in human melanoma cells in vitro and delays growth of melanoma xenografts. FEBS Letters 553, 250-256.

Hu, Y.-P., Haq, B., Carraway, K. L., Savaraj, N., and Lampidis, T. J. (2003). Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma cells. Biochemical Pharmacology 65, 1419-1425.

Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., and Simon, M. C. (2003). Differential Roles of Hypoxia-Inducible Factor 1{alpha} (HIF-1{alpha}) and HIF-2{alpha} in Hypoxic Gene Regulation. Mol Cell Biol 23, 9361-9374.

Hu, S. X., Wang, S., Wang, J. P., Mills, G. B., Zhou, Y., and Xu, H. J. (2003). Expression of endogenous granzyme B in a subset of human primary breast carcinomas. Br J Cancer 89, 135-139.

Huang, S., Qu, L. K., Cuddihy, A. R., Ragheb, R., Taya, Y., and Koromilas, A. E. (2003). Protein kinase inhibitor 2-aminopurine overrides multiple genotoxic stress-induced cellular pathways to promote cell survival. Oncogene 22, 3721-3733.

Huang, F., Jiang, X., and Sorkin, A. (2003). Tyrosine Phosphorylation of the {beta}2 Subunit of Clathrin Adaptor Complex AP-2 Reveals the Role of a Di-leucine Motif in the Epidermal Growth Factor Receptor Trafficking. J Biol Chem 278, 43411-43417.

Hudson, D. F., Vagnarelli, P., Gassmann, R., and Earnshaw, W. C. (2003). Condensin Is Required for Nonhistone Protein Assembly and Structural Integrity of Vertebrate Mitotic Chromosomes. Developmental Cell 5, 323-336.

Huettner, C. S., Koschmieder, S., Iwasaki, H., Iwasaki-Arai, J., Radomska, H. S., Akashi, K., and Tenen, D. G. (2003). Inducible expression of BCR/ABL using human CD34 regulatory elements results in a megakaryocytic myeloproliferative syndrome. Blood 102, 3363-3370.

Husken, D., Asselbergs, F., Kinzel, B., Natt, F., Weiler, J., Martin, P., Haner, R., and Hall, J. (2003). mRNA fusion constructs serve in a general cell-based assay to profile oligonucleotide activity. Nucl Acids Res 31, e102-.

Hwang, D. Y., Cho, J. S., Chae, K. R., Kang, T. S., Hwang, J. H., Lim, C. H., Lee, S. H., Lim, H. J., Min, S. H., and Sheen, Y. Y. (2003). Differential expression of the tetracycline-controlled transactivator-driven human CYP1B1 gene in double-transgenic mice is due to androgens: application for detecting androgens and antiandrogens. Archives of Biochemistry and Biophysics 415, 137-145.

Hwang, S. O., Chung, J. Y., and Lee, G. M. (2003). Effect of doxycycline-regulated ERp57 expression on specific thrombopoietin productivity of recombinant CHO cells. Biotechnol Prog 19, 179-184.

Igarashi, N., Okada, T., Hayashi, S., Fujita, T., Jahangeer, S., and Nakamura, S.-i. (2003). Sphingosine Kinase 2 Is a Nuclear Protein and Inhibits DNA Synthesis. J Biol Chem 278, 46832-46839.

Igarashi, S., Morita, H., Bennett, K. M., Tanaka, Y., Engelender, S., Peters, M. F., Cooper, J. K., Wood, J. D., Sawa, A., and Ross, C. A. (2003). Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation. Neuroreport 14, 565-568.

Igney, F. H., Behrens, C. K., and Krammer, P. H. (2003). The influence of CD95L expression on tumor rejection in mice. Eur J Immunol 33, 2811-2821.

Igoucheva, O., Alexeev, V., Pryce, M., and Yoon, K. (2003). Transcription affects formation and processing of intermediates in oligonucleotide-mediated gene alteration. Nucl Acids Res 31, 2659-2670.

Ikonomov, O. C., Sbrissa, D., Foti, M., Carpentier, J.-L., and Shisheva, A. (2003). PIKfyve Controls Fluid Phase Endocytosis but Not Recycling/Degradation of Endocytosed Receptors or Sorting of Procathepsin D by Regulating Multivesicular Body Morphogenesis. Mol Biol Cell 14, 4581-4591.

Ikonomov, O. C., Sbrissa, D., Mlak, K., Deeb, R., Fligger, J., Soans, A., Finley, R. L., Jr., and Shisheva, A. (2003). Active PIKfyve Associates with and Promotes the Membrane Attachment of the Late Endosome-to-trans-Golgi Network Transport Factor Rab9 Effector p40. J Biol Chem 278, 50863-50871.

Isik, S., Sano, K., Tsutsui, K., Seki, M., Enomoto, T., Saitoh, H., and Tsutsui, K. (2003). The SUMO pathway is required for selective degradation of DNA topoisomerase II[beta] induced by a catalytic inhibitor ICRF-193. FEBS Letters 546, 374-378.

Iversen, T.-G., Skretting, G., van Deurs, B., and Sandvig, K. (2003). From the Cover: Clathrin-coated pits with long, dynamin-wrapped necks upon expression of a clathrin antisense RNA. PNAS 100, 5175-5180.

Jackman, M., Lindon, C., Nigg, E. A., and Pines, J. (2003). Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol 5, 143-148.

Jackson, A. P., Flett, A., Smythe, C., Hufton, L., Wettey, F. R., and Smythe, E. (2003). Clathrin promotes incorporation of cargo into coated pits by activation of the AP2 adaptor {micro}2 kinase. J Cell Biol 163, 231-236.

Jandt, E., Denner, K., Kovalenko, M., Ostman, A., and Bohmer, F. D. (2003). The protein-tyrosine phosphatase DEP-1 modulates growth factor-stimulated cell migration and cell-matrix adhesion. Oncogene 22, 4175-4185.

Jaubert, J., Cheng, J., and Segre, J. A. (2003). Ectopic expression of Kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier. Development 130, 2767-2777.

Ji, X., Kong, J., and Liebhaber, S. A. (2003). In Vivo Association of the Stability Control Protein {alpha}CP with Actively Translating mRNAs. Mol Cell Biol 23, 899-907.

Jia, Y.-J., Kai, M., Wada, I., Sakane, F., and Kanoh, H. (2003). Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells. FEBS Letters 552, 240-246.

Jia, W., Yu, C., Rahmani, M., Krystal, G., Sausville, E. A., Dent, P., and Grant, S. (2003). Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways. Blood 102, 1824-1832.

Jiang, N., Benard, C. Y., Kebir, H., Shoubridge, E. A., and Hekimi, S. (2003). Human CLK2 Links Cell Cycle Progression, Apoptosis, and Telomere Length Regulation. J Biol Chem 278, 21678-21684.

Jimenez, A. L., Chou, A. H., Khadadadi, O., Palos, T. P., and Howard, B. D. (2003). Wnt-1 has multiple effects on the expression of glutamate transporters. Neurochemistry International 42, 345-351.

Jin, C., Fu, W.-X., Xie, L.-P., Qian, X.-P., and Chen, W.-F. (2003). SDF-1[alpha] production is negatively regulated by mouse estrogen enhanced transcript in a mouse thymus epithelial cell line. Cellular Immunology 223, 26-34.

Jin, S., Mazzacurati, L., Zhu, X., Tong, T., Song, Y., Shujuan, S., Petrik, K. L., Rajasekaran, B., Wu, M., and Zhan, Q. (2003). Gadd45a contributes to p53 stabilization in response to DNA damage. Oncogene 22, 8536-8540.

Joerges, C., Kuntze, I., and Herzinge, T. (2003). Induction of a caffeine-sensitive S-phase cell cycle checkpoint by psoralen plus ultraviolet A radiation. Oncogene 22, 6119-6128.

Joseph, B., Wallen-Mackenzie, A., Benoit, G., Murata, T., Joodmardi, E., Okret, S., and Perlmann, T. (2003). p57Kip2 cooperates with Nurr1 in developing dopamine cells. PNAS 100, 15619-15624.

Jouvenceau, A., Billard, J. M., Haditsch, U., Mansuy, I. M., and Dutar, P. (2003). Different phosphatase-dependent mechanisms mediate long-term depression and depotentiation of long-term potentiation in mouse hippocampal CA1 area. Eur J Neurosci 18, 1279-1285.

Kamikubo, Y., Takaori-Kondo, A., Uchiyama, T., and Hori, T. (2003). Inhibition of Cell Growth by Conditional Expression of kpm, a Human Homologue of Drosophila warts/lats Tumor Suppressor. J Biol Chem 278, 17609-17614.

Kanaji, S., Kanaji, T., Furihata, K., Kato, K., Ware, J. L., and Kunicki, T. J. (2003). Convulxin Binds to Native, Human Glycoprotein Ib{alpha}. J Biol Chem 278, 39452-39460.

Kanda, E., Jin, Z.-H., Mizuchi, D., Arai, A., and Miura, O. (2003). Activation of Rac and tyrosine phosphorylation of cytokine receptors induced by cross-linking of integrin [alpha]4[beta]1 and cell adhesion in hematopoietic cells. Biochemical and Biophysical Research Communications 301, 934-940.

Kanemaki, M., Sanchez-Diaz, A., Gambus, A., and Labib, K. (2003). Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Nature 423, 720-724.

Kang, Y., Chen, C.-R., and Massague, J. (2003). A Self-Enabling TGF[beta] Response Coupled to Stress Signaling: Smad Engages Stress Response Factor ATF3 for Id1 Repression in Epithelial Cells. Molecular Cell 11, 915-926.

Karlsson, A., Giuriato, S., Tang, F., Fung-Weier, J., Levan, G., and Felsher, D. W. (2003). Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations. Blood 101, 2797-2803.

Kashima, T., and Manley, J. L. (2003). A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy. Nat Genet 34, 460-463.

Kazerounian, S., and Aho, S. (2003). Characterization of Periphilin, a Widespread, Highly Insoluble Nuclear Protein and Potential Constituent of the Keratinocyte Cornified Envelope. J Biol Chem 278, 36707-36717.

Kilarski, W. W., Jura, N., and Gerwins, P. (2003). Inactivation of Src family kinases inhibits angiogenesis in vivo: implications for a mechanism involving organization of the actin cytoskeleton. Experimental Cell Research 291, 70-82.

Kim, M.-R., Chang, H.-S., Kim, B.-H., Kim, S., Baek, S.-H., Hye Kim, J., Lee, S.-R., and Kim, J.-R. (2003). Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferation. Biochemical and Biophysical Research Communications 304, 119-124.

Kim, B. O., Liu, Y., Ruan, Y., Xu, Z. C., Schantz, L., and He, J. J. (2003). Neuropathologies in Transgenic Mice Expressing Human Immunodeficiency Virus Type 1 Tat Protein under the Regulation of the Astrocyte-Specific Glial Fibrillary Acidic Protein Promoter and Doxycycline. Am J Pathol 162, 1693-1707.

Kim, J. H., Lee, S., Park, J. B., Lee, S. D., Kim, J. H., Ha, S. H., Hasumi, K., Endo, A., Suh, P.-G., and Ryu, S. H. (2003). Hydrogen peroxide induces association between glyceraldehyde 3-phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells. J Neurochem 85, 1228-1236.

Kim, I. K., Jung, Y. K., Noh, D. Y., Song, Y. S., Choi, C. H., Oh, B. H., and Masuda, E. S. (2003). Functional screening of genes suppressing TRAIL-induced apoptosis: distinct inhibitory activities of Bcl-XL and Bcl-2. Br J Cancer 88, 910-917.

Kim, J. H., Lee, S., Park, J. B., Lee, S. D., Ha, S. H., Hasumi, K., Endo, A., Suh, P. G., and Ryu, S. H. (2003). Hydrogen peroxide induces association between glyceraldehyde 3-phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells. J Neurochem 85, 1228-1236.

King, S. L., Marks, M. J., Grady, S. R., Caldarone, B. J., Koren, A. O., Mukhin, A. G., Collins, A. C., and Picciotto, M. R. (2003). Conditional Expression in Corticothalamic Efferents Reveals a Developmental Role for Nicotinic Acetylcholine Receptors in Modulation of Passive Avoidance Behavior. J Neurosci 23, 3837-1707.

Kinoshita, I., Leaner, V., Katabami, M., Manzano, R. G., Dent, P., Sabichi, A., and Birrer, M. J. (2003). Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth. Oncogene 22, 2710-2722.

Kissil, J. L., Wilker, E. W., Johnson, K. C., Eckman, M. S., Yaffe, M. B., and Jacks, T. (2003). Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1. Molecular Cell 12, 841-849.

Kitani, A., Fuss, I., Nakamura, K., Kumaki, F., Usui, T., and Strober, W. (2003). Transforming Growth Factor (TGF)-{beta}1-producing Regulatory T Cells Induce Smad-mediated Interleukin 10 Secretion That Facilitates Coordinated Immunoregulatory Activity and Amelioration of TGF-{beta}1-mediated Fibrosis. J Exp Med 198, 1179-1188.

Knauf, J. A., Ouyang, B., Croyle, M., Kimura, E., and Fagin, J. A. (2003). Acute expression of RET/PTC induces isozyme-specific activation and subsequent downregulation of PKCepsilon in PCCL3 thyroid cells. Oncogene 22, 6830-6838.

Knott, A., Muller, Y., Zunino, S. J., Berens, C., and Hillen, W. (2003). Conditional cell suicide using dox-dependent caspase-2 expression. J Gene Med 5, 343-354.

Kojima, K., Musch, M. W., Ropeleski, M. J., Boone, D. L., Ma, A., and Chang, E. B. (2003). E. coli Lipopolysaccharide Induces Heat Shock Protein 25 in Intestinal Epithelial Cells Through MAP Kinase Activation. Am J Physiol Gastrointest Liver Physiol, 00080.02003.

Kong, J., Ji, X., and Liebhaber, S. A. (2003). The KH-Domain Protein {alpha}CP Has a Direct Role in mRNA Stabilization Independent of Its Cognate Binding Site. Mol Cell Biol 23, 1125-1134.

Koponen, J. K., Kankkonen, H., Kannasto, J., Wirth, T., Hillen, W., Bujard, H., and Yla-Herttuala, S. (2003). Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo. Gene Ther 10, 459-466.

Kouvaraki, M. A., Rassidakis, G. Z., Tian, L., Kumar, R., Kittas, C., and Claret, F.-X. (2003). Jun Activation Domain-binding Protein 1 Expression in Breast Cancer Inversely Correlates with the Cell Cycle Inhibitor p27Kip1. Cancer Res 63, 2977-2981.

Kovacic, S., Soltys, C.-L. M., Barr, A. J., Shiojima, I., Walsh, K., and Dyck, J. R. B. (2003). Akt Activity Negatively Regulates Phosphorylation of AMP-activated Protein Kinase in the Heart. J Biol Chem 278, 39422-39427.

Kramer, B. P., Weber, W., and Fussenegger, M. (2003). Artificial regulatory networks and cascades for discrete multilevel transgene control in mammalian cells. Biotechnol Bioeng 83, 810-820.

Kraus, T. A., Lau, J. F., Parisien, J.-P., and Horvath, C. M. (2003). A Hybrid IRF9-STAT2 Protein Recapitulates Interferon-stimulated Gene Expression and Antiviral Response. J Biol Chem 278, 13033-13038.

Krueger, C., Berens, C., Schmidt, A., Schnappinger, D., and Hillen, W. (2003). Single-chain Tet transregulators. Nucl Acids Res 31, 3050-3056.

Krummrei, U., Baulieu, E.-E., and Chambraud, B. (2003). The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis. PNAS 100, 2444-2449.

Kryndushkin, D. S., Alexandrov, I. M., Ter-Avanesyan, M. D., and Kushnirov, V. V. (2003). Yeast [PSI+] Prion Aggregates Are Formed by Small Sup35 Polymers Fragmented by Hsp104. J Biol Chem 278, 49636-49643.

Kubo, S., and Mitani, K. (2003). A New Hybrid System Capable of Efficient Lentiviral Vector Production and Stable Gene Transfer Mediated by a Single Helper-Dependent Adenoviral Vector. J Virol 77, 2964-2971.

Kudoh, A., Fujita, M., Kiyono, T., Kuzushima, K., Sugaya, Y., Izuta, S., Nishiyama, Y., and Tsurumi, T. (2003). Reactivation of Lytic Replication from B Cells Latently Infected with Epstein-Barr Virus Occurs with High S-Phase Cyclin-Dependent Kinase Activity while Inhibiting Cellular DNA Replication. J Virol 77, 851-861.

Kumar, M. J., Nicholls, D. G., and Andersen, J. K. (2003). Oxidative {alpha}-Ketoglutarate Dehydrogenase Inhibition via Subtle Elevations in Monoamine Oxidase B Levels Results in Loss of Spare Respiratory Capacity: IMPLICATIONS FOR PARKINSON'S DISEASE. J Biol Chem 278, 46432-46439.

Kwaks, T. H., Barnett, P., Hemrika, W., Siersma, T., Sewalt, R. G., Satijn, D. P., Brons, J. F., van Blokland, R., Kwakman, P., Kruckeberg, A. L., et al. (2003). Identification of anti-repressor elements that confer high and stable protein production in mammalian cells. Nat Biotechnol 21, 553-558.

Kyba, M., Perlingeiro, R. C. R., Hoover, R. R., Lu, C.-W., Pierce, J., and Daley, G. Q. (2003). Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5. PNAS 100, 11904-11910.

Lai, J.-F., Juang, S.-H., Hung, Y.-M., Cheng, H.-Y., Cheng, T.-L., Mostov, K. E., and Jou, T.-S. (2003). An ecdysone and tetracycline dual regulatory expression system for studies on Rac1 small GTPase-mediated signaling. Am J Physiol Cell Physiol 285, C711-719.

Lamartina, S., Silvi, L., Roscilli, G., Casimiro, D., Simon, A. J., Davies, M.-E., Shiver, J. W., Rinaudo, C. D., Zampaglione, I., and Fattori, E. (2003). Construction of an rtTA2s-m2/ttskid-Based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and Non-Human primates. Molecular Therapy 7, 271-280.

Lan, H. Y., Mu, W., Tomita, N., Huang, X. R., Li, J. H., Zhu, H.-J., Morishita, R., and Johnson, R. J. (2003). Inhibition of Renal Fibrosis by Gene Transfer of Inducible Smad7 Using Ultrasound-Microbubble System in Rat UUO Model. J Am Soc Nephrol 14, 1535-1548.

Landis, G. N., Bhole, D., and Tower, J. (2003). A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes. Genome Biol 4, R8. Epub 2003 Jan 2030.

Laney, J. D., and Hochstrasser, M. (2003). Ubiquitin-dependent degradation of the yeast Mat{alpha}2 repressor enables a switch in developmental state. Genes Dev 17, 2259-2270.

Laposa, R. R., Henderson, J. T., and Wells, P. G. (2003). Tetracycline-dependent regulation of formamidopyrimidine DNA glycosylase in transgenic mice conditionally reduces oxidative DNA damage in vivo. FASEB J, 02-0689fje.

Lavelle, D., DeSimone, J., Hankewych, M., Kousnetzova, T., and Chen, Y.-H. (2003). Decitabine induces cell cycle arrest at the G1 phase via p21WAF1 and the G2/M phase via the p38 MAP kinase pathway. Leukemia Research 27, 999-1007.

Le, P. U., and Nabi, I. R. (2003). Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum. J Cell Sci 116, 1059-1071.

Le, X.-F., Claret, F.-X., Lammayot, A., Tian, L., Deshpande, D., LaPushin, R., Tari, A. M., and Bast, R. C., Jr. (2003). The Role of Cyclin-dependent Kinase Inhibitor p27Kip1 in Anti-HER2 Antibody-induced G1 Cell Cycle Arrest and Tumor Growth Inhibition. J Biol Chem 278, 23441-23450.

Leaner, V. D., Kinoshita, I., and Birrer, M. J. (2003). AP-1 complexes containing cJun and JunB cause cellular transformation of Rat1a fibroblasts and share transcriptional targets. Oncogene 22, 5619-5629.

Lee, S. S., Kim, Y. M., Junn, E., Lee, G., Park, K.-H., Tanaka, M., Ronchetti, R. D., Quezado, M. M., and Mouradian, M. M. (2003). Cell cycle aberrations by [alpha]-synuclein over-expression and cyclin B immunoreactivity in Lewy bodies. Neurobiology of Aging 24, 687-696.

Lee, A.-H., Iwakoshi, N. N., and Glimcher, L. H. (2003). XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response. Mol Cell Biol 23, 7448-7459.

Li, Y., Xie, M., Song, X., Gragen, S., Sachdeva, K., Wan, Y., and Yan, B. (2003). DEC1 Negatively Regulates the Expression of DEC2 through Binding to the E-box in the Proximal Promoter. J Biol Chem 278, 16899-16907.

Li, J. H., Huang, X. R., Zhu, H.-J., Oldfield, M., Cooper, M., Truong, L. D., Johnson, R. J., and Lan, H. Y. (2003). Advanced glycation end products activate Smad signaling via TGF-β-dependent and -independent mechanisms: implications for diabetic renal and vascular disease. FASEB J.

Li, D., Kashii, S., Sahara, T., and Ito, K. (2003). Adeno-associated virus type 2 Rep40 modulates the proliferation rate of Rep52-expressing HeLa cells. Intervirology 46, 127-134.

Li, J. H., Huang, X. R., Zhu, H. J., Johnson, R., and Lan, H. Y. (2003). Role of TGF-beta signaling in extracellular matrix production under high glucose conditions. Kidney Int 63, 2010-2019.

Lin, Q., Fuji, R. N., Yang, W., and Cerione, R. A. (2003). RhoGDI Is Required for Cdc42-Mediated Cellular Transformation. Current Biology 13, 1469-1479.

Lin, P.-F., Blair, W., Wang, T., Spicer, T., Guo, Q., Zhou, N., Gong, Y.-F., Wang, H.-G. H., Rose, R., Yamanaka, G., et al. (2003). From the Cover: A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding. PNAS 100, 11013-11018.

Lin, J., and Weiss, A. (2003). The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J Cell Biol 162, 673-682.

Lin, S.-Y., and Elledge, S. J. (2003). Multiple Tumor Suppressor Pathways Negatively Regulate Telomerase. Cell 113, 881-889.

Lin, H.-K., Hu, Y.-C., Yang, L., Altuwaijri, S., Chen, Y.-T., Kang, H.-Y., and Chang, C. (2003). Suppression Versus Induction of Androgen Receptor Functions by the Phosphatidylinositol 3-Kinase/Akt Pathway in Prostate Cancer LNCaP Cells with Different Passage Numbers. J Biol Chem 278, 50902-50907.

Lipschutz, J. H., Lingappa, V. R., and Mostov, K. E. (2003). The Exocyst Affects Protein Synthesis by Acting on the Translocation Machinery of the Endoplasmic Reticulum. J Biol Chem 278, 20954-20960.

Liu, X., Mayeda, A., Tao, M., and Zheng, Z.-M. (2003). Exonic Splicing Enhancer-Dependent Selection of the Bovine Papillomavirus Type 1 Nucleotide 3225 3' Splice Site Can Be Rescued in a Cell Lacking Splicing Factor ASF/SF2 through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway. J Virol 77, 2105-2115.

Liu, Z., Xu, X., Hsu, H.-C., Tousson, A., Yang, P.-A., Wu, Q., Liu, C., Yu, S., Zhang, H.-G., and Mountz, J. D. (2003). CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis. J Clin Invest 112, 1332-1341.

Liu, C., Goshu, E., Wells, A., and Fan, C.-M. (2003). Identification of the Downstream Targets of SIM1 and ARNT2, a Pair of Transcription Factors Essential for Neuroendocrine Cell Differentiation. J Biol Chem 278, 44857-44867.

Long, J., Matsuura, I., He, D., Wang, G., Shuai, K., and Liu, F. (2003). Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT. PNAS 100, 9791-9796.

Lopez, R. G., Carron, C., and Ghysdael, J. (2003). v-SRC Specifically Regulates the Nucleo-cytoplasmic Delocalization of the Major Isoform of TEL (ETV6). J Biol Chem 278, 41316-41325.

Low, S. H., Li, X., Miura, M., Kudo, N., Quinones, B., and Weimbs, T. (2003). Syntaxin 2 and Endobrevin Are Required for the Terminal Step of Cytokinesis in Mammalian Cells. Developmental Cell 4, 753-759.

Luker, G. D., Sharma, V., Pica, C. M., Prior, J. L., Li, W., and Piwnica-Worms, D. (2003). Molecular Imaging of Protein-Protein Interactions: Controlled Expression of p53 and Large T-Antigen Fusion Proteins in Vivo. Cancer Res 63, 1780-1788.

Luo, X., Huang, Y., and Sheikh, M. S. (2003). Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation. Oncogene 22, 7247-7257.

Lynch, C. J., Halle, B., Fujii, H., Vary, T. C., Wallin, R., Damuni, Z., and Hutson, S. M. (2003). Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR. Am J Physiol Endocrinol Metab 285, E854-863.

Lyu, J., Costantini, F., Jho, E.-h., and Joo, C.-k. (2003). Ectopic Expression of Axin Blocks Neuronal Differentiation of Embryonic Carcinoma P19 Cells. J Biol Chem 278, 13487-13495.

Ma, D., Zhou, P., and Harbour, J. W. (2003). Distinct Mechanisms for Regulating the Tumor Suppressor and Antiapoptotic Functions of Rb. J Biol Chem 278, 19358-19366.

Macdonald, A., Crowder, K., Street, A., McCormick, C., Saksela, K., and Harris, M. (2003). The Hepatitis C Virus Non-structural NS5A Protein Inhibits Activating Protein-1 Function by Perturbing Ras-ERK Pathway Signaling. J Biol Chem 278, 17775-17784.

Macip, S., Igarashi, M., Berggren, P., Yu, J., Lee, S. W., and Aaronson, S. A. (2003). Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions. Mol Cell Biol 23, 8576-8585.

Mahon, G. M., Wang, Y., Korus, M., Kostenko, E., Cheng, L., Sun, T., Arlinghaus, R. B., and Whitehead, I. P. (2003). The c-Myc Oncoprotein Interacts with Bcr. Current Biology 13, 437-441.

Malerba, M., Daeffler, L., Rommelaere, J., and Iggo, R. D. (2003). Replicating Parvoviruses That Target Colon Cancer Cells. J Virol 77, 6683-6691.

Mallo, M., Kanzler, B., and Ohnemus, S. (2003). Reversible gene inactivation in the mouse. Genomics 81, 356-360.

Manfra, D. J., Chen, S.-C., Jensen, K. K., Fine, J. S., Wiekowski, M. T., and Lira, S. A. (2003). Conditional Expression of Murine Flt3 Ligand Leads to Expansion of Multiple Dendritic Cell Subsets in Peripheral Blood and Tissues of Transgenic Mice. J Immunol 170, 2843-3014.

Mao, Y., and Muller, M. T. (2003). Down modulation of topoisomerase I affects DNA repair efficiency. DNA Repair 2, 1115-1126.

Margosio, B., Marchetti, D., Vergani, V., Giavazzi, R., Rusnati, M., Presta, M., and Taraboletti, G. (2003). Thrombospondin 1 as a scavenger for matrix-associated fibroblast growth factor 2. Blood 102, 4399-4406.

Martel-Renoir, D., Trochon-Joseph, V., Galaup, A., Bouquet, C., Griscelli, F., Opolon, P., Opolon, D., Connault, E., Mir, L., and Perricaudet, M. (2003). Coelectrotransfer to skeletal muscle of three plasmids coding for antiangiogenic factors and regulatory factors of the tetracycline-inducible system: tightly regulated expression, inhibition of transplanted tumor growth, and antimetastatic effect. Molecular Therapy 8, 425-433.

Martinez-Arca, S., Rudge, R., Vacca, M., Raposo, G., Camonis, J., Proux-Gillardeaux, V., Daviet, L., Formstecher, E., Hamburger, A., Filippini, F., et al. (2003). A dual mechanism controlling the localization and function of exocytic v-SNAREs. PNAS 100, 9011-9016.

Mattenberger, Y., James, D. I., and Martinou, J.-C. (2003). Fusion of mitochondria in mammalian cells is dependent on the mitochondrial inner membrane potential and independent of microtubules or actin. FEBS Letters 538, 53-59.

Matushansky, I., Radparvar, F., and Skoultchi, A. I. (2003). CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells. Oncogene 22, 4143-4149.

Maul, R. S., Song, Y., Amann, K. J., Gerbin, S. C., Pollard, T. D., and Chang, D. D. (2003). EPLIN regulates actin dynamics by cross-linking and stabilizing filaments. J Cell Biol 160, 399-407.

McConnell, M. J., Chevallier, N., Berkofsky-Fessler, W., Giltnane, J. M., Malani, R. B., Staudt, L. M., and Licht, J. D. (2003). Growth Suppression by Acute Promyelocytic Leukemia-Associated Protein PLZF Is Mediated by Repression of c-myc Expression. Mol Cell Biol 23, 9375-9388.

Meissner, U., Allabauer, I., Repp, R., Rascher, W., and Dotsch, J. (2003). Inducible expression of hypoxia-inducible factor 1alpha (HIF-1alpha) as a tool for studying HIF-1alpha-dependent gene regulation during normoxia in vitro. Pharmacology 69, 74-78.

Melton, K. R., Nesslein, L. L., Ikegami, M., Tichelaar, J. W., Clark, J. C., Whitsett, J. A., and Weaver, T. E. (2003). SP-B deficiency causes respiratory failure in adult mice. Am J Physiol Lung Cell Mol Physiol 285, L543-549.

Meyer, T. N., Hunt, J., Schwesinger, C., and Denker, B. M. (2003). G{alpha}12 regulates epithelial cell junctions through Src tyrosine kinases. Am J Physiol Cell Physiol 285, C1281-1293.

Mils, V., Yuen Lee, S. M., Joly, W., Hang, E. W. C., Baldin, V. e., Waye, M. M. Y., Ducommun, B., and Tsui, S. K. W. (2003). LIM-only protein FHL3 interacts with CDC25B2 phosphatase. Experimental Cell Research 285, 99-106.

Mimori, K., Shiraishi, T., Mashino, K., Sonoda, H., Yamashita, K., Yoshinaga, K., Masuda, T., Utsunomiya, T., Alonso, M. A., Inoue, H., and Mori, M. (2003). MAL gene expression in esophageal cancer suppresses motility, invasion and tumorigenicity and enhances apoptosis through the Fas pathway. Oncogene 22, 3463-3471.

Min, K.-W., Hwang, J.-W., Lee, J.-S., Park, Y., Tamura, T.-a., and Yoon, J.-B. (2003). TIP120A Associates with Cullins and Modulates Ubiquitin Ligase Activity. J Biol Chem 278, 15905-15910.

Mishra, S., Reichert, A., Cunnick, J., Senadheera, D., Hemmeryckx, B., Heisterkamp, N., and Groffen, J. (2003). Protein kinase CKIIalpha interacts with the Bcr moiety of Bcr/Abl and mediates proliferation of Bcr/Abl-expressing cells. Oncogene 22, 8255-8262.

Mittler, G., Stuhler, T., Santolin, L., Uhlmann, T., Kremmer, E., Lottspeich, F., Berti, L., and Meisterernst, M. (2003). A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. EMBO J 22, 6494-6504.

Miyake, S., Yanagisawa, Y., and Yuasa, Y. (2003). A Novel EID-1 Family Member, EID-2, Associates with Histone Deacetylases and Inhibits Muscle Differentiation. J Biol Chem 278, 17060-17065.

Mizuguchi, H., Xu, Z. L., Sakurai, F., Mayumi, T., and Hayakawa, T. (2003). Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions. Hum Gene Ther 14, 1265-1277.

Mizuno, K., Suzuki, A., Hirose, T., Kitamura, K., Kutsuzawa, K., Futaki, M., Amano, Y., and Ohno, S. (2003). Self-association of PAR-3-mediated by the Conserved N-terminal Domain Contributes to the Development of Epithelial Tight Junctions. J Biol Chem 278, 31240-31250.

Mo, C., Lee, J., Sommer, M. H., and Arvin, A. M. (2003). Varicella-zoster virus infection facilitates VZV glycoprotein E trafficking to the membrane surface of melanoma cells. J Med Virol 70, S56-58.

Mohan, W. S., II, Scheer, E., Wendling, O., Metzger, D., and Tora, L. (2003). TAF10 (TAFII30) Is Necessary for TFIID Stability and Early Embryogenesis in Mice. Mol Cell Biol 23, 4307-4318.

Mohan, R. R., Possin, D. E., Mohan, R. R., Sinha, S., and Wilson, S. E. (2003). Development of genetically engineered tet HPV16-E6/E7 transduced human corneal epithelial clones having tight regulation of proliferation and normal differentiation. Experimental Eye Research 77, 395-407.

Moldes, M., Zuo, Y., Morrison, R. F., Silva, D., Park, B. H., Liu, J., and Farmer, S. R. (2003). Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis. Biochem J 376, 607-613.

Monte, M., Benetti, R., Buscemi, G., Sandy, P., Del Sal, G., and Schneider, C. (2003). The Cell Cycle-regulated Protein Human GTSE-1 Controls DNA Damage-induced Apoptosis by Affecting p53 Function. J Biol Chem 278, 30356-30364.

Morozov, A., Muzzio, I. A., Bourtchouladze, R., Van-Strien, N., Lapidus, K., Yin, D., Winder, D. G., Adams, J. P., Sweatt, J. D., and Kandel, E. R. (2003). Rap1 Couples cAMP Signaling to a Distinct Pool of p42/44MAPK Regulating Excitability, Synaptic Plasticity, Learning, and Memory. Neuron 39, 309-325.

Morozov, A., Kellendonk, C., Simpson, E., and Tronche, F. (2003). Using conditional mutagenesis to study the brain. Biological Psychiatry 54, 1125-1133.

Morris, D. G., Huang, X., Kaminski, N., Wang, Y., Shapiro, S. D., Dolganov, G., Glick, A., and Sheppard, D. (2003). Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature 422, 169-173.

Mu, X., and Chang, C. (2003). TR3 Orphan Nuclear Receptor Mediates Apoptosis through Up-regulating E2F1 in Human Prostate Cancer LNCaP Cells. J Biol Chem 278, 42840-42845.

Mucenski, M. L., Wert, S. E., Nation, J. M., Loudy, D. E., Huelsken, J., Birchmeier, W., Morrisey, E. E., and Whitsett, J. A. (2003). {beta}-Catenin Is Required for Specification of Proximal/Distal Cell Fate during Lung Morphogenesis. J Biol Chem 278, 40231-40238.

Muckenthaler, M., Richter, A., Gunkel, N., Riedel, D., Polycarpou-Schwarz, M., Hentze, S., Falkenhahn, M., Stremmel, W., Ansorge, W., and Hentze, M. W. (2003). Relationships and distinctions in iron-regulatory networks responding to interrelated signals. Blood 101, 3690-3698.

Muljo, S. A., and Schlissel, M. S. (2003). A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Nat Immunol 4, 31-37.

Nabors, L. B., Suswam, E., Huang, Y., Yang, X., Johnson, M. J., and King, P. H. (2003). Tumor Necrosis Factor {alpha} Induces Angiogenic Factor Up-Regulation in Malignant Glioma Cells: A Role for RNA Stabilization and HuR. Cancer Res 63, 4181-4187.

Nadav, E., Shmueli, A., Barr, H., Gonen, H., Ciechanover, A., and Reiss, Y. (2003). A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1. Biochemical and Biophysical Research Communications 303, 91-97.

Nagano, Y., Yamashita, H., Takahashi, T., Kishida, S., Nakamura, T., Iseki, E., Hattori, N., Mizuno, Y., Kikuchi, A., and Matsumoto, M. (2003). Siah-1 Facilitates Ubiquitination and Degradation of Synphilin-1. J Biol Chem 278, 51504-51514.

Nagao, T., Higashitsuji, H., Nonoguchi, K., Sakurai, T., Dawson, S., Mayer, R. J., Itoh, K., and Fujita, J. (2003). MAGE-A4 Interacts with the Liver Oncoprotein Gankyrin and Suppresses Its Tumorigenic Activity. J Biol Chem 278, 10668-10674.

Nahreini, P., Hanson, A. J., and Prasad, K. N. (2003). Enrichment of cells exhibiting tetracycline regulated gene expression. Biotechniques 34, 958-962, 964, 966 passim.

Nakamura, H., Lu, M., Gwack, Y., Souvlis, J., Zeichner, S. L., and Jung, J. U. (2003). Global Changes in Kaposi's Sarcoma-Associated Virus Gene Expression Patterns following Expression of a Tetracycline-Inducible Rta Transactivator. J Virol 77, 4205-4220.

Newmyer, S. L., Christensen, A., and Sever, S. (2003). Auxilin-Dynamin Interactions Link the Uncoating ATPase Chaperone Machinery with Vesicle Formation. Developmental Cell 4, 929-940.

Ng, C. C., Arakawa, H., Fukuda, S., Kondoh, H., and Nakamura, Y. (2003). p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. Oncogene 22, 4449-4458.

Nguyen, M. T., Lue, H., Kleemann, R., Thiele, M., Tolle, G., Finkelmeier, D., Wagner, E., Braun, A., and Bernhagen, J. (2003). The Cytokine Macrophage Migration Inhibitory Factor Reduces Pro-Oxidative Stress-Induced Apoptosis. J Immunol 170, 3337-3014.

Nicholas, B., Smethurst, P., Verderio, E., Jones, R., and Griffin, M. (2003). Cross-linking of cellular proteins by tissue transglutaminase during necrotic cell death: a mechanism for maintaining tissue integrity. Biochem J 371, 413-422.

Niemann, H., and Kues, W. A. (2003). Application of transgenesis in livestock for agriculture and biomedicine. Animal Reproduction Science 79, 291-317.

Nimmanapalli, R., Bali, P., O'Bryan, E., Fuino, L., Guo, F., Wu, J., Houghton, P., and Bhalla, K. (2003). Arsenic Trioxide Inhibits Translation of mRNA of bcr-abl, Resulting in Attenuation of Bcr-Abl Levels and Apoptosis of Human Leukemia Cells. Cancer Res 63, 7950-7958.

Nimnual, A. S., Taylor, L. J., and Bar-Sagi, D. (2003). Redox-dependent downregulation of Rho by Rac. Nat Cell Biol 5, 236-241.

Nishimoto, M., Miyagi, S., Katayanagi, T., Tomioka, M., Muramatsu, M., and Okuda, A. (2003). The embryonic Octamer factor 3/4 displays distinct DNA binding specificity from those of other Octamer factors. Biochemical and Biophysical Research Communications 302, 581-586.

Nishimura, K., Ueda, K., Sakakibara, S., Do, E., Ohsaki, E., Okuno, T., and Yamanishi, K. (2003). A viral transcriptional activator of Kaposi's sarcoma-associated herpesvirus (KSHV) induces apoptosis, which is blocked in KSHV-infected cells. Virology 316, 64-74.

Norton, P. A., Gong, Q., Mehta, A. S., Lu, X., and Block, T. M. (2003). Hepatitis B Virus-Mediated Changes of Apolipoprotein mRNA Abundance in Cultured Hepatoma Cells. J Virol 77, 5503-5506.

NOTT, A., MEISLIN, S. H., and MOORE, M. J. (2003). A quantitative analysis of intron effects on mammalian gene expression. RNA 9, 607-1707.

Nozell, S., Wu, Y., McNaughton, K., Liu, G., Willis, A., Paik, J. C., and Chen, X. (2003). Characterization of p73 functional domains necessary for transactivation and growth suppression. Oncogene 22, 4333-4347.

Numaguchi, Y., Huang, S., Polte, T. R., Eichler, G. S., Wang, N., and Ingber, D. E. (2003). Caldesmon-dependent switching between capillary endothelial cell growth and apoptosis through modulation of cell shape and contractility. Angiogenesis 6, 55-64.

Nyfeler, B., Nufer, O., Matsui, T., Mori, K., and Hauri, H.-P. (2003). The cargo receptor ERGIC-53 is a target of the unfolded protein response. Biochemical and Biophysical Research Communications 304, 599-604.

Oesterreich, S., Deng, W., Jiang, S., Cui, X., Ivanova, M., Schiff, R., Kang, K., Hadsell, D. L., Behrens, J., and Lee, A. V. (2003). Estrogen-mediated Down-Regulation of E-cadherin in Breast Cancer Cells. Cancer Res 63, 5203-5208.

Oh, W. K., and Song, J. (2003). Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation. Mol Cells 16, 84-91.

Okoye, G., Zimmer, J., Sung, J., Gehlbach, P., Deering, T., Nambu, H., Hackett, S., Melia, M., Esumi, N., Zack, D. J., and Campochiaro, P. A. (2003). Increased Expression of Brain-Derived Neurotrophic Factor Preserves Retinal Function and Slows Cell Death from Rhodopsin Mutation or Oxidative Damage. J Neurosci 23, 4164-1707.

Oleinik, N. V., and Krupenko, S. A. (2003). Ectopic expression of 10-formyltetrahydrofolate dehydrogenase in A549 cells induces G1 cell cycle arrest and apoptosis. Mol Cancer Res 1, 577-588.

Oluwatosin-Chigbu, Y., Robbins, A., Scott, C. W., Arriza, J. L., Reid, J. D., and Zysk, J. R. (2003). Parkin suppresses wild-type [alpha]-synuclein-induced toxicity in SHSY-5Y cells. Biochemical and Biophysical Research Communications 309, 679-684.

Ongusaha, P. P., Kim, J.-i., Fang, L., Wong, T. W., Yancopoulos, G. D., Aaronson, S. A., and Lee, S. W. (2003). p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J 22, 1289-1301.

Ouvrard-Pascaud, A., and Jaisser, F. (2003). Pathophysiological role of the mineralocorticoid receptor in heart: analysis of conditional transgenic models. Pflugers Archiv-European Journal of Physiology 445, 477-481.

Page, K., Li, J., Zhou, L., Iasvoyskaia, S., Corbit, K. C., Soh, J.-W., Weinstein, I. B., Brasier, A. R., Lin, A., and Hershenson, M. B. (2003). Regulation of Airway Epithelial Cell NF-{kappa}B-Dependent Gene Expression by Protein Kinase C{delta}. J Immunol 170, 5681-5689.

Palosaari, H., Parisien, J.-P., Rodriguez, J. J., Ulane, C. M., and Horvath, C. M. (2003). STAT Protein Interference and Suppression of Cytokine Signal Transduction by Measles Virus V Protein. J Virol 77, 7635-7644.

Pan, Y., and Chen, J. (2003). MDM2 Promotes Ubiquitination and Degradation of MDMX. Mol Cell Biol 23, 5113-5121.

Panka, D. J., and Mier, J. W. (2003). Canstatin Inhibits Akt Activation and Induces Fas-dependent Apoptosis in Endothelial Cells. J Biol Chem 278, 37632-37636.

Pao, W., Klimstra, D. S., Fisher, G. H., and Varmus, H. E. (2003). Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance. PNAS 100, 8764-8769.

Passer, B. J., Nancy-Portebois, V., Amzallag, N., Prieur, S., Cans, C., Roborel de Climens, A., Fiucci, G., Bouvard, V., Tuynder, M., Susini, L., et al. (2003). The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. PNAS 100, 2284-2289.

Paul, D. S., Harmon, A. W., Winston, C. P., and Patel, Y. M. (2003). Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes. Biochem J 376, 625-632.

Pavio, N., Romano, P. R., Graczyk, T. M., Feinstone, S. M., and Taylor, D. R. (2003). Protein Synthesis and Endoplasmic Reticulum Stress Can Be Modulated by the Hepatitis C Virus Envelope Protein E2 through the Eukaryotic Initiation Factor 2{alpha} Kinase PERK. J Virol 77, 3578-3585.

Peakman, M.-C., Colby, C., Perrotti, L. I., Tekumalla, P., Carle, T., Ulery, P., Chao, J., Duman, C., Steffen, C., and Monteggia, L. (2003). Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Research 970, 73-86.

Peart, M. J., Tainton, K. M., Ruefli, A. A., Dear, A. E., Sedelies, K. A., O'Reilly, L. A., Waterhouse, N. J., Trapani, J. A., and Johnstone, R. W. (2003). Novel Mechanisms of Apoptosis Induced by Histone Deacetylase Inhibitors. Cancer Res 63, 4460-4471.

Peng, W.-T., Robinson, M. D., Mnaimneh, S., Krogan, N. J., Cagney, G., Morris, Q., Davierwala, A. P., Grigull, J., Yang, X., and Zhang, W. (2003). A Panoramic View of Yeast Noncoding RNA Processing. Cell 113, 919-933.

Perkins, K. D., Gregonis, J., Borge, S., and Rice, S. A. (2003). Transactivation of a Viral Target Gene by Herpes Simplex Virus ICP27 Is Posttranscriptional and Does Not Require the Endogenous Promoter or Polyadenylation Site. J Virol 77, 9872-9884.

Perl, A.-K. T., Hokuto, I., Impagnatiello, M.-A., Christofori, G., and Whitsett, J. A. (2003). Temporal effects of Sprouty on lung morphogenesis. Developmental Biology 258, 154-168.

Peyruchaud, O., Serre, C.-M., NicAmhlaoibh, R., Fournier, P., and Clezardin, P. (2003). Angiostatin Inhibits Bone Metastasis Formation in Nude Mice through a Direct Anti-osteoclastic Activity. J Biol Chem 278, 45826-45832.

Pichierri, P., Rosselli, F., and Franchitto, A. (2003). Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle. Oncogene 22, 1491-1500.

Plas, D. R., and Thompson, C. B. (2003). Akt Activation Promotes Degradation of Tuberin and FOXO3a via the Proteasome. J Biol Chem 278, 12361-12366.

Plath, K., Fang, J., Mlynarczyk-Evans, S. K., Cao, R., Worringer, K. A., Wang, H., de la Cruz, C. C., Otte, A. P., Panning, B., and Zhang, Y. (2003). Role of Histone H3 Lysine 27 Methylation in X Inactivation. Science 300, 131-135.

Polcic, P., and Forte, M. (2003). Response of yeast to the regulated expression of proteins in the Bcl-2 family. Biochem J 374, 393-402.

POLLOCK, A. S., TURCK, J., and LOVETT, D. H. (2003). The prodomain of interleukin 1{alpha} interacts with elements of the RNA processing apparatus and induces apoptosis in malignant cells. FASEB J 17, 203-213.

Porcellini, A., Messina, S., De Gregorio, G., Feliciello, A., Carlucci, A., Barone, M., Picascia, A., De Blasi, A., and Avvedimento, E. V. (2003). The Expression of the Thyroid-stimulating Hormone (TSH) Receptor and the cAMP-dependent Protein Kinase RII {beta} Regulatory Subunit Confers TSH-cAMP-dependent Growth to Mouse Fibroblasts. J Biol Chem 278, 40621-40630.

Post, S. M., Tomkinson, A. E., and Lee, E. Y.-H. P. (2003). The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase {epsilon}. Nucl Acids Res 31, 5568-5575.

Prehaud, C., Lay, S., Dietzschold, B., and Lafon, M. (2003). Glycoprotein of Nonpathogenic Rabies Viruses Is a Key Determinant of Human Cell Apoptosis. J Virol 77, 10537-10547.

Priault, M., Cartron, P. F., Camougrand, N., Antonsson, B., Vallette, F. M., and Manon, S. (2003). Investigation of the role of the C-terminus of Bax and of tc-Bid on Bax interaction with yeast mitochondria. Cell Death Differ 10, 1068-1077.

Prigent, M., Dubois, T., Raposo, G., Derrien, V., Tenza, D., Rosse, C., Camonis, J., and Chavrier, P. (2003). ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. J Cell Biol 163, 1111-1121.

Pujuguet, P., Del Maestro, L., Gautreau, A., Louvard, D., and Arpin, M. (2003). Ezrin Regulates E-Cadherin-dependent Adherens Junction Assembly through Rac1 Activation. Mol Biol Cell 14, 2181-2191.

Puxeddu, E., Mitsutake, N., Knauf, J. A., Moretti, S., Kim, H. W., Seta, K. A., Brockman, D., Myatt, L., Millhorn, D. E., and Fagin, J. A. (2003). Microsomal Prostaglandin E2 Synthase-1 Is Induced by Conditional Expression of RET/PTC in Thyroid PCCL3 Cells through the Activation of the MEK-ERK Pathway. J Biol Chem 278, 52131-52138.

Queralt, E., and Igual, J. C. (2003). Cell Cycle Activation of the Swi6p Transcription Factor Is Linked to Nucleocytoplasmic Shuttling. Mol Cell Biol 23, 3126-3140.

Quinn, J. E., Kennedy, R. D., Mullan, P. B., Gilmore, P. M., Carty, M., Johnston, P. G., and Harkin, D. P. (2003). BRCA1 Functions as a Differential Modulator of Chemotherapy-induced Apoptosis. Cancer Res 63, 6221-6228.

Rachidi, W., Vilette, D., Guiraud, P., Arlotto, M., Riondel, J., Laude, H., Lehmann, S., and Favier, A. (2003). Expression of Prion Protein Increases Cellular Copper Binding and Antioxidant Enzyme Activities but Not Copper Delivery. J Biol Chem 278, 9064-9072.

Radu, A., Neubauer, V., Akagi, T., Hanafusa, H., and Georgescu, M.-M. (2003). PTEN Induces Cell Cycle Arrest by Decreasing the Level and Nuclear Localization of Cyclin D1. Mol Cell Biol 23, 6139-6149.

Rahman, M. M., Miyamoto, H., Lardy, H., and Chang, C. (2003). Inactivation of androgen receptor coregulator ARA55 inhibits androgen receptor activity and agonist effect of antiandrogens in prostate cancer cells. PNAS 100, 5124-5129.

Rahmani, M., Yu, C., Dai, Y., Reese, E., Ahmed, W., Dent, P., and Grant, S. (2003). Coadministration of the Heat Shock Protein 90 Antagonist 17-Allylamino- 17-demethoxygeldanamycin with Suberoylanilide Hydroxamic Acid or Sodium Butyrate Synergistically Induces Apoptosis in Human Leukemia Cells. Cancer Res 63, 8420-8427.

Rahmani, M., Yu, C., Reese, E., Ahmed, W., Hirsch, K., Dent, P., and Grant, S. (2003). Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition. Oncogene 22, 6231-6242.

Rajasekaran, S. A., Anilkumar, G., Oshima, E., Bowie, J. U., Liu, H., Heston, W., Bander, N. H., and Rajasekaran, A. K. (2003). A Novel Cytoplasmic Tail MXXXL Motif Mediates the Internalization of Prostate-specific Membrane Antigen. Mol Biol Cell 14, 4835-4845.

Ravikumar, B., Stewart, A., Kita, H., Kato, K., Duden, R., and Rubinsztein, D. C. (2003). Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet 12, 985-994.

Ray, P., Devaux, Y., Stolz, D. B., Yarlagadda, M., Watkins, S. C., Lu, Y., Chen, L., Yang, X.-f., and Ray, A. (2003). Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia. PNAS 100, 6098-6103.

Reeder, J. E., Sowden, M. P., Messing, E. M., Klover, P., Villa-Moruzzi, E., and Ludlow, J. W. (2003). Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line. Cancer Cell Int 3, 12.

Regulier, E., Trottier, Y., Perrin, V., Aebischer, P., and Deglon, N. (2003). Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum. Hum Mol Genet 12, 2827-2836.

Reichenbach, P., Hoss, M., Azzalin, C. M., Nabholz, M., Bucher, P., and Lingner, J. (2003). A Human Homolog of Yeast Est1 Associates with Telomerase and Uncaps Chromosome Ends When Overexpressed. Current Biology 13, 568-574.

Rennel, E., Cross, M. J., Klint, P., Bai, X., Arbiser, J. L., and Gerwins, P. (2003). Regulation of endothelial cell differentiation and transformation by H-Ras. Experimental Cell Research 291, 189-200.

Renner, K., Amberger, A., Konwalinka, G., Kofler, R., and Gnaiger, E. (2003). Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1642, 115-123.

Reynolds, P. A., Smolen, G. A., Palmer, R. E., Sgroi, D., Yajnik, V., Gerald, W. L., and Haber, D. A. (2003). Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein. Genes Dev 17, 2094-2107.

Rocha, S., Martin, A. M., Meek, D. W., and Perkins, N. D. (2003). p53 Represses Cyclin D1 Transcription through Down Regulation of Bcl-3 and Inducing Increased Association of the p52 NF-{kappa}B Subunit with Histone Deacetylase 1. Mol Cell Biol 23, 4713-4727.

Roemer, T., Jiang, B., Davison, J., Ketela, T., Veillette, K., Breton, A., Tandia, F., Linteau, A., Sillaots, S., Marta, C., et al. (2003). Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol Microbiol 50, 167-181.

Rogers, K. K., Jou, T. S., Guo, W., and Lipschutz, J. H. (2003). The Rho family of small GTPases is involved in epithelial cystogenesis and tubulogenesis. Kidney Int 63, 1632-1644.

Romagnoli, A., Oliverio, S., Evangelisti, C., Iannicola, C., Ippolito, G., and Piacentini, M. (2003). Neuroleukin inhibition sensitises neuronal cells to caspase-dependent apoptosis. Biochemical and Biophysical Research Communications 302, 448-453.

Rong, R., Ahn, J.-Y., Chen, P., Suh, P.-G., and Ye, K. (2003). Phospholipase Activity of Phospholipase C-{gamma}1 Is Required for Nerve Growth Factor-regulated MAP Kinase Signaling Cascade in PC12 Cells. J Biol Chem 278, 52497-52503.

Roovers, K., and Assoian, R. K. (2003). Effects of Rho Kinase and Actin Stress Fibers on Sustained Extracellular Signal-Regulated Kinase Activity and Activation of G1 Phase Cyclin-Dependent Kinases. Mol Cell Biol 23, 4283-4294.

Roshal, M., Kim, B., Zhu, Y., Nghiem, P., and Planelles, V. (2003). Activation of the ATR-mediated DNA Damage Response by the HIV-1 Viral Protein R. J Biol Chem 278, 25879-25886.

Roth, A., Gill, R., and Certa, U. (2003). Temporal and spatial gene expression patterns after experimental stroke in a rat model and characterization of PC4, a potential regulator of transcription. Molecular and Cellular Neuroscience 22, 353-364.

Sablina, A. A., Chumakov, P. M., and Kopnin, B. P. (2003). Tumor Suppressor p53 and Its Homologue p73{alpha} Affect Cell Migration. J Biol Chem 278, 27362-27371.

Sanbe, A., Gulick, J., Hanks, M. C., Liang, Q., Osinska, H., and Robbins, J. (2003). Reengineering Inducible Cardiac-Specific Transgenesis With an Attenuated Myosin Heavy Chain Promoter. Circ Res 92, 609-328.

Sarig, R., Zaltsman, Y., Marcellus, R. C., Flavell, R., Mak, T. W., and Gross, A. (2003). BID-D59A Is a Potent Inducer of Apoptosis in Primary Embryonic Fibroblasts. J Biol Chem 278, 10707-10715.

Sarker, K. P., Biswas, K. K., Yamakuchi, M., Lee, K.-Y., Hahiguchi, T., Kracht, M., Kitajima, I., and Maruyama, I. (2003). ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death. J Neurochem 85, 50-61.

Sato, N., Sato, M., Nakayama, M., Saitoh, R., Arai, K., and Masai, H. (2003). Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7-ASK kinase complex. Genes Cells 8, 451-463.

Satou, M., Aizawa, S., Hayakari, M., Ookawa, K., and Tsuchida, S. (2003). Enhanced sensitivity to cis-diamminedichloroplatinum(II) of a human carcinoma cell line with mutated p53 gene by cyclin-dependent kinase inhibitor p21(WAF1) expression. Cancer Sci 94, 286-291.

Scherr, M., Battmer, K., Winkler, T., Heidenreich, O., Ganser, A., and Eder, M. (2003). Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood 101, 1566-1569.

Schiffer, I. B., Gebhard, S., Heimerdinger, C. K., Heling, A., Hast, J., Wollscheid, U., Seliger, B., Tanner, B., Gilbert, S., Beckers, T., et al. (2003). Switching Off HER-2/neu in a Tetracycline-Controlled Mouse Tumor Model Leads to Apoptosis and Tumor-Size-Dependent Remission. Cancer Res 63, 7221-7231.

Schilling, R., Ijaz, S., Davidoff, M., Lee, J. Y., Locarnini, S., Williams, R., and Naoumov, N. V. (2003). Endocytosis of Hepatitis B Immune Globulin into Hepatocytes Inhibits the Secretion of Hepatitis B Virus Surface Antigen and Virions. J Virol 77, 8882-8892.

Schlosser, I., Holzel, M., Murnseer, M., Burtscher, H., Weidle, U. H., and Eick, D. (2003). A role for c-Myc in the regulation of ribosomal RNA processing. Nucl Acids Res 31, 6148-6156.

Schonig, K., and Bujard, H. (2003). Generating conditional mouse mutants via tetracycline-controlled gene expression. Methods Mol Biol 209, 69-104.

Schubert, W., Yang, X. Y., Yang, T. T. C., Factor, S. M., Lisanti, M. P., Molkentin, J. D., Rincon, M., and Chow, C.-W. (2003). Requirement of transcription factor NFAT in developing atrial myocardium. J Cell Biol 161, 861-874.

Schuh, W., Meister, S., Roth, E., and Jack, H.-M. (2003). Cutting Edge: Signaling and Cell Surface Expression of a {micro}H Chain in the Absence of {lambda}5: A Paradigm Revisited. J Immunol 171, 3343-3347.

Scougall, K. T., and Shaw, J. A. M. (2003). Tetracycline-regulated secretion of human insulin in transfected primary myoblasts. Biochemical and Biophysical Research Communications 304, 167-175.

Seddon, B., Tomlinson, P., and Zamoyska, R. (2003). Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol 4, 680-686.

Seike, M., Kondo, T., Mori, Y., Gemma, A., Kudoh, S., Sakamoto, M., Yamada, T., and Hirohashi, S. (2003). Proteomic Analysis of Intestinal Epithelial Cells Expressing Stabilized {beta}-Catenin. Cancer Res 63, 4641-4647.

Seki, K., Fujimori, T., Savagner, P., Hata, A., Aikawa, T., Ogata, N., Nabeshima, Y., and Kaechoong, L. (2003). Mouse Snail Family Transcription Repressors Regulate Chondrocyte, Extracellular Matrix, Type II Collagen, and Aggrecan. J Biol Chem 278, 41862-41870.

Seminario, M. C., Precht, P., Wersto, R. P., Gorospe, M., and Wange, R. L. (2003). PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression. Oncogene 22, 8195-8204.

Sengupta, S., Linke, S. P., Pedeux, R., Yang, Q., Farnsworth, J., Garfield, S. H., Valerie, K., Shay, J. W., Ellis, N. A., Wasylyk, B., and Harris, C. C. (2003). BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. EMBO J 22, 1210-1222.

Seong, Y.-S., Min, C., Li, L., Yang, J. Y., Kim, S.-Y., Cao, X., Kim, K., Yuspa, S. H., Chung, H.-H., and Lee, K. S. (2003). Characterization of a Novel Cyclin-Dependent Kinase 1 Inhibitor, BMI-1026 Cancer Res 63, 7384-7391.

Seyfried, J., Evert, B. O., Schwarz, C. S., Schaupp, M., Schulz, J. B., Klockgether, T., and Wullner, U. (2003). Gene dosage-dependent effects of bcl-2 expression on cellular survival and redox status. Free Radical Biology and Medicine 34, 1517-1530.

Shan, B., Xu, J., Zhuo, Y., Morris, C. A., and Morris, G. F. (2003). Induction of p53-dependent Activation of the Human Proliferating Cell Nuclear Antigen Gene in Chromatin by Ionizing Radiation. J Biol Chem 278, 44009-44017.

Sharma, S., tenOever, B. R., Grandvaux, N., Zhou, G.-P., Lin, R., and Hiscott, J. (2003). Triggering the Interferon Antiviral Response Through an IKK-Related Pathway. Science 300, 1148-1151.

Shibanuma, M., Kim-Kaneyama, J.-r., Ishino, K., Sakamoto, N., Hishiki, T., Yamaguchi, K., Mori, K., Mashimo, J.-i., and Nose, K. (2003). Hic-5 Communicates between Focal Adhesions and the Nucleus through Oxidant-Sensitive Nuclear Export Signal. Mol Biol Cell 14, 1158-1171.

Shigehara, T., Zaragoza, C., Kitiyakara, C., Takahashi, H., Lu, H., Moeller, M., Holzman, L. B., and Kopp, J. B. (2003). Inducible podocyte-specific gene expression in transgenic mice. J Am Soc Nephrol 14, 1998-2003.

Shih, W.-L., Kuo, M.-L., Chuang, S.-E., Cheng, A.-L., and Doong, S.-L. (2003). Hepatitis B Virus X Protein Activates a Survival Signaling by Linking Src to Phosphatidylinositol 3-Kinase. J Biol Chem 278, 31807-31813.

Shiio, Y., Eisenman, R. N., Yi, E. C., Donohoe, S., Goodlett, D. R., and Aebersold, R. (2003). Quantitative proteomic analysis of chromatin-associated factors. Journal of the American Society for Mass Spectrometry 14, 696-703.

Shimozaki, K., Nakashima, K., Niwa, H., and Taga, T. (2003). Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures. Development 130, 2505-2512.

Shin, H.-J., Baek, K.-H., Jeon, A.-H., Park, M.-T., Lee, S.-J., Kang, C.-M., Lee, H.-S., Yoo, S.-H., Chung, D.-H., and Sung, Y.-C. (2003). Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell 4, 483-497.

Shtutman, M., Hershko, T., Maissel, A., Fima, E., and Livneh, E. (2003). PKC[eta] associates with cyclin E/Cdk2 complex in serum-starved MCF-7 and NIH-3T3 cells. Experimental Cell Research 286, 22-29.

Shyu, H.-W., Hsu, S.-H., Hsieh-Li, H.-M., and Li, H. (2003). Forced expression of RNF36 induces cell apoptosis. Experimental Cell Research 287, 301-313.

Siddiqui, H., Solomon, D. A., Gunawardena, R. W., Wang, Y., and Knudsen, E. S. (2003). Histone Deacetylation of RB-Responsive Promoters: Requisite for Specific Gene Repression but Dispensable for Cell Cycle Inhibition. Mol Cell Biol 23, 7719-7731.

Siegers, K., Bolter, B., Schwarz, J. P., Bottcher, U. M. K., Guha, S., and Hartl, F. U. (2003). TRiC/CCT cooperates with different upstream chaperones in the folding of distinct protein classes. EMBO J 22, 5230-5240.

Silvertown, J. D., Geddes, B. J., and Summerlee, A. J. S. (2003). Adenovirus-Mediated Expression of Human Prorelaxin Promotes the Invasive Potential of Canine Mammary Cancer Cells. Endocrinology 144, 3683-3691.

Simon, E., Barcelo, A., and Arino, J. (2003). Mutagenesis analysis of the yeast Nha1 Na+/H+ antiporter carboxy-terminal tail reveals residues required for function in cell cycle. FEBS Letters 545, 239-245.

Sirk, D. P., Zhu, Z., Wadia, J. S., and Mills, L. R. (2003). Flow cytometry and GFP: a novel assay for measuring the import and turnover of nuclear-encoded mitochondrial proteins in live PC12 cells. Cytometry 56A, 15-22.

Slade, N., Zaika, A. I., Erster, S., and Moll, U. M. (2003). DeltaNp73 stabilises TAp73 proteins but compromises their function due to inhibitory hetero-oligomer formation. Cell Death Differ 12, 12.

Slutsky, S. G., Kamaraju, A. K., Levy, A. M., Chebath, J., and Revel, M. (2003). Activation of Myelin Genes during Transdifferentiation from Melanoma to Glial Cell Phenotype. J Biol Chem 278, 8960-8968.

Snyers, L., Zwickl, H., and Blaas, D. (2003). Human Rhinovirus Type 2 Is Internalized by Clathrin-Mediated Endocytosis. J Virol 77, 5360-5369.

Sobol, R. W., Foley, J. F., Nyska, A., Davidson, M. G., and Wilson, S. H. (2003). Regulated over-expression of DNA polymerase [beta] mediates early onset cataract in mice. DNA Repair 2, 609-622.

Song, K. S., Lee, W.-J., Chung, K. C., Koo, J. S., Yang, E. J., Choi, J. Y., and Yoon, J.-H. (2003). Interleukin-1{beta} and Tumor Necrosis Factor-{alpha} Induce MUC5AC Overexpression through a Mechanism Involving ERK/p38 Mitogen-activated Protein Kinases-MSK1-CREB Activation in Human Airway Epithelial Cells. J Biol Chem 278, 23243-23250.

Song, S., Kim, S.-Y., Hong, Y.-M., Jo, D.-G., Lee, J.-Y., Shim, S. M., Chung, C.-W., Seo, S. J., Yoo, Y. J., and Koh, J.-Y. (2003). Essential Role of E2-25K/Hip-2 in Mediating Amyloid-[beta] Neurotoxicity. Molecular Cell 12, 553-563.

Song, K. S., Seong, J.-K., Chung, K. C., Lee, W.-J., Kim, C.-H., Cho, K. N., Kang, C.-D., Koo, J. S., and Yoon, J.-H. (2003). Induction of MUC8 Gene Expression by Interleukin-1{beta} Is Mediated by a Sequential ERK MAPK/RSK1/CREB Cascade Pathway in Human Airway Epithelial Cells. J Biol Chem 278, 34890-34896.

Spitzer, D., Dittmar, K. E. J., Rohde, M., Hauser, H., and Wirth, D. (2003). Green Fluorescent Protein-Tagged Retroviral Envelope Protein for Analysis of Virus-Cell Interactions. J Virol 77, 6070-6075.

Spurlin, B. A., Thomas, R. M., Nevins, A. K., Kim, H. J., Kim, Y. J., Noh, H. L., Shulman, G. I., Kim, J. K., and Thurmond, D. C. (2003). Insulin resistance in tetracycline-repressible Munc18c transgenic mice. Diabetes 52, 1910-1917.

Srour, N., Lebel, A., McMahon, S., Fournier, I., Fugere, M., Day, R., and Dubois, C. M. (2003). TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity. FEBS Letters 554, 275-283.

Stilo, R., Liguoro, D., di Jeso, B., Leonardi, A., and Vito, P. (2003). The [alpha]-chain of the nascent polypeptide-associated complex binds to and regulates FADD function. Biochemical and Biophysical Research Communications 303, 1034-1041.

Stoica, G. E., Franke, T. F., Wellstein, A., Morgan, E., Czubayko, F., List, H. J., Reiter, R., Martin, M. B., and Stoica, A. (2003). Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway. Oncogene 22, 2073-2087.

Straub, J. A., Lipscomb, E. A., Yoshida, E. S., and Freeman, R. S. (2003). Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death. J Neurochem 85, 318-328.

Sturniolo, M. T., Dashti, S. R., Deucher, A., Rorke, E. A., Broome, A.-M., Chandraratna, R. A. S., Keepers, T., and Eckert, R. L. (2003). A Novel Tumor Suppressor Protein Promotes Keratinocyte Terminal Differentiation via Activation of Type I Transglutaminase. J Biol Chem 278, 48066-48073.

Su, L., Hattori, M., Moriyama, M., Murata, N., Harazaki, M., Kaibuchi, K., and Minato, N. (2003). AF-6 Controls Integrin-mediated Cell Adhesion by Regulating Rap1 Activation through the Specific Recruitment of Rap1GTP and SPA-1. J Biol Chem 278, 15232-15238.

Su, Y., Ishikawa, S., Kojima, M., and Liu, B. (2003). Eradication of pathogenic {beta}-catenin by Skp1/Cullin/F box ubiquitination machinery. PNAS 100, 12729-12734.

Su, L., Agati, J. M., and Parsons, S. J. (2003). p190RhoGAP is cell cycle regulated and affects cytokinesis. J Cell Biol 163, 571-582.

Suetsugu, S., and Takenawa, T. (2003). Translocation of N-WASP by Nuclear Localization and Export Signals into the Nucleus Modulates Expression of HSP90. J Biol Chem 278, 42515-42523.

Sunters, A., Thomas, D. P., Yeudall, W. A., and Grigoriadis, A. E. (2003). Accelerated cell cycle progression in osteoblasts overexpressing the c-fos proto-oncogene: Induction of cyclin A and enhanced CDK2 activity. J Biol Chem, M310184200.

Suzuki, K., Nakajima, H., Ikeda, K., Maezawa, Y., Suto, A., Takatori, H., Saito, Y., and Iwamoto, I. (2003). IL-4-Stat6 Signaling Induces Tristetraprolin Expression and Inhibits TNF-{alpha} Production in Mast Cells. J Exp Med 198, 1717-1727.

Suzuki, T., Fukuo, K., Suhara, T., Yasuda, O., Sato, N., Takemura, Y., Tsubakimoto, M., and Ogihara, T. (2003). Eicosapentaenoic Acid Protects Endothelial Cells Against Anoikis Through Restoration of cFLIP. Hypertension 42, 342-348.

Swanton, E., High, S., and Woodman, P. (2003). Role of calnexin in the glycan-independent quality control of proteolipid protein. EMBO J 22, 2948-2958.

Swaroop, M., and Sun, Y. (2003). Mdm2 ligase dead mutants did not act in a dominant negative manner to re-activate p53, but promoted tumor cell growth. Anticancer Res 23, 3167-3174.

Taharaguchi, S., Kon, Y., Yoshino, S., and Ono, E. (2003). Impaired development of the cerebellum in transgenic mice expressing the immediate-early protein IE180 of pseudorabies virus. Virology 307, 243-254.

Takahashi, K., Saishin, Y., Silva, R. L., Oshima, Y., Oshima, S., Melia, M., Paszkiet, B., Zerby, D., Kadan, M. J., Liau, G., et al. (2003). Intraocular expression of endostatin reduces VEGF-induced retinal vascular permeability, neovascularization, and retinal detachment. Faseb J 17, 896-898.

Tamarina, N. A., Wang, Y., Mariotto, L., Kuznetsov, A., Bond, C., Adelman, J., and Philipson, L. H. (2003). Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses. Diabetes 52, 2000-2006.

Tan, K. H., and Hunziker, W. (2003). Compartmentalization of fas and fas ligand may prevent auto- or paracrine apoptosis in epithelial cells. Experimental Cell Research 284, 281-288.

Tanahashi-Hori, T., Tanahashi, N., Tanaka, K., and Chiba, T. (2003). Conditional Knockdown of Proteasomes Results in Cell-cycle Arrest and Enhanced Expression of Molecular Chaperones Hsp70 and Hsp40 in Chicken DT40 Cells. J Biol Chem 278, 16237-16243.

Tang, T. T.-L., and Lasky, L. A. (2003). The Forkhead Transcription Factor FOXO4 Induces the Down-regulation of Hypoxia-inducible Factor 1{alpha} by a von Hippel-Lindau Protein-independent Mechanism. J Biol Chem 278, 30125-30135.

Taylor, M. S., Bonev, A. D., Gross, T. P., Eckman, D. M., Brayden, J. E., Bond, C. T., Adelman, J. P., and Nelson, M. T. (2003). Altered Expression of Small-Conductance Ca2+-Activated K+ (SK3) Channels Modulates Arterial Tone and Blood Pressure. Circ Res 93, 124-131.

Thorburn, J., Bender, L. M., Morgan, M. J., and Thorburn, A. (2003). Caspase- and Serine Protease-dependent Apoptosis by the Death Domain of FADD in Normal Epithelial Cells. Mol Biol Cell 14, 67-77.

Tietge, U. J., Kozarsky, K. F., Donahee, M. H., and Rader, D. J. (2003). A tetracycline-regulated adenoviral expression system for in vivo delivery of transgenes to lung and liver. J Gene Med 5, 567-575.

Tilli, M. T., Hudgins, S. L., Frech, M. S., Halama, E. D., Renou, J.-P., and Furth, P. A. (2003). Loss of Protein Phosphatase 2A Expression Correlates with Phosphorylation of DP-1 and Reversal of Dysplasia through Differentiation in a Conditional Mouse Model of Cancer Progression. Cancer Res 63, 7668-7673.

Tilli, M. T., and Furth, P. A. (2003). Conditional mouse models demonstrate oncogene-dependent differences in tumor maintenance and recurrence. Breast Cancer Res 5, 202-205. Epub 2003 May 2030.

Tirado, O. M., Mateo-Lozano, S., Sanders, S., Dettin, L. E., and Notario, V. (2003). The PCPH Oncoprotein Antagonizes the Proapoptotic Role of the Mammalian Target of Rapamycin in the Response of Normal Fibroblasts to Ionizing Radiation. Cancer Res 63, 6290-6298.

Tochikura, T. S., Xiao, S., Ego, T., Sagara, J., and Kawai, A. (2003). Further characterization of a CD99-related 21-kDa transmembrane protein (VAP21) expressed in Syrian hamster cells and its possible involvement in vesicular stomatitis virus production. Microbiol Immunol 47, 745-757.

Tokuzawa, Y., Kaiho, E., Maruyama, M., Takahashi, K., Mitsui, K., Maeda, M., Niwa, H., and Yamanaka, S. (2003). Fbx15 Is a Novel Target of Oct3/4 but Is Dispensable for Embryonic Stem Cell Self-Renewal and Mouse Development. Mol Cell Biol 23, 2699-2708.

Topisirovic, I., Culjkovic, B., Cohen, N., Perez, J. M., Skrabanek, L., and Borden, K. L. B. (2003). The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth. EMBO J 22, 689-703.

Townson, S. M., Dobrzycka, K. M., Lee, A. V., Air, M., Deng, W., Kang, K., Jiang, S., Kioka, N., Michaelis, K., and Oesterreich, S. (2003). SAFB2, a New Scaffold Attachment Factor Homolog and Estrogen Receptor Corepressor. J Biol Chem 278, 20059-20068.

Tran, H., Maurer, F., and Nagamine, Y. (2003). Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2. Mol Cell Biol 23, 7177-7188.

Tran, S. E., Meinander, A., Holmstrom, T. H., Rivero-Muller, A., Heiskanen, K. M., Linnau, E. K., Courtney, M. J., Mosser, D. D., Sistonen, L., and Eriksson, J. E. (2003). Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis. Cell Death Differ 10, 1137-1147.

Trapani, J. A., Sutton, V. R., Thia, K. Y. T., Li, Y. Q., Froelich, C. J., Jans, D. A., Sandrin, M. S., and Browne, K. A. (2003). A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J Cell Biol 160, 223-407.

Tsang, F. C., Po, L. S., Leung, K. M., Lau, A., Siu, W. Y., and Poon, R. Y. C. (2003). ING1b decreases cell proliferation through p53-dependent and -independent mechanisms. FEBS Letters 553, 277-285.

Tse, S. M. L., Furuya, W., Gold, E., Schreiber, A. D., Sandvig, K., Inman, R. D., and Grinstein, S. (2003). Differential Role of Actin, Clathrin, and Dynamin in Fcgamma Receptor-mediated Endocytosis and Phagocytosis. J Biol Chem 278, 3331-3338.

Tsuchiya, K., Kawano, Y., Kojima, T., Nagata, K., Takao, T., Okada, M., Shinohara, H., Maki, K., Toyama-Sorimachi, N., and Miyasaka, N. (2003). Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. FEBS Letters 537, 203-209.

Tullo, A., Mastropasqua, G., Bourdon, J. C., Centonze, P., Gostissa, M., Costanzo, A., Levrero, M., Sal, G. D., Saccone, C., and Sbisa, E. (2003). Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target. Oncogene 22, 8738-8748.

Turano, M., Tammaro, A., De Biase, I., Lo Casale, M. S., Ruggiero, G., Monticelli, A., Cocozza, S., and Pianese, L. (2003). 3-Nitropropionic acid increases frataxin expression in human lymphoblasts and in transgenic rat PC12 cells. Neuroscience Letters 350, 184-186.

Ucur, E., Mattern, J., Wenger, T., Okouoyo, S., Schroth, A., Debatin, K. M., and Herr, I. (2003). Induction of apoptosis in experimental human B cell lymphomas by conditional TRAIL-expressing T cells. Br J Cancer 89, 2155-2162.

Ueberham, E., Low, R., Ueberham, U., Schonig, K., Bujard, H., and Gebhardt, R. (2003). Conditional tetracycline-regulated expression of TGF-[beta]1 in liver of transgenic mice leads to reversible intermediary fibrosis. Hepatology 37, 1067-1078.

Ueda, M., Ota, J., Yamashita, Y., Choi, Y. L., Ohki, R., Wada, T., Koinuma, K., Kano, Y., Ozawa, K., and Mano, H. (2003). DNA microarray analysis of stage progression mechanism in myelodysplastic syndrome. Br J Haematol 123, 288-296.

Valenta, T., Lukas, J., and Korinek, V. (2003). HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells. Nucl Acids Res 31, 2369-2380.

Van Der Luit, A. H., Budde, M., Verheij, M., and Van Blitterswijk, W. J. (2003). Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine. Biochem J 374, 747-753.

van Grunsven, L. A., Michiels, C., Van de Putte, T., Nelles, L., Wuytens, G., Verschueren, K., and Huylebroeck, D. (2003). Interaction between Smad-interacting Protein-1 and the Corepressor C-terminal Binding Protein Is Dispensable for Transcriptional Repression of E-cadherin. J Biol Chem 278, 26135-26145.

Van Itallie, C. M., Fanning, A. S., and Anderson, J. M. (2003). Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins. Am J Physiol Renal Physiol 285, F1078-1084.

Van Mullem, V., Wery, M., De Bolle, X., and Vandenhaute, J. (2003). Construction of a set of Saccharomyces cerevisiae vectors designed for recombinational cloning. Yeast 20, 739-746.

van Noesel, M. M., Pieters, R., Voute, P. A., and Versteeg, R. (2003). The N-myc paradox: N-myc overexpression in neuroblastomas is associated with sensitivity as well as resistance to apoptosis. Cancer Letters 197, 165-172.

Verderio, E. A. M., Telci, D., Okoye, A., Melino, G., and Griffin, M. (2003). A Novel RGD-independent Cell Adhesion Pathway Mediated by Fibronectin-bound Tissue Transglutaminase Rescues Cells from Anoikis. J Biol Chem 278, 42604-42614.

Vernell, R., Helin, K., and Muller, H. (2003). Identification of Target Genes of the p16INK4A-pRB-E2F Pathway. J Biol Chem 278, 46124-46137.

Vervoorts, J., Luscher-Firzlaff, J. M., Rottmann, S., Lilischkis, R., Walsemann, G., Dohmann, K., Austen, M., and Luscher, B. (2003). Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP. EMBO Reports 4, 484-490.

Vishnyakova, T. G., Bocharov, A. V., Baranova, I. N., Chen, Z., Remaley, A. T., Csako, G., Eggerman, T. L., and Patterson, A. P. (2003). Binding and Internalization of Lipopolysaccharide by Cla-1, a Human Orthologue of Rodent Scavenger Receptor B1. J Biol Chem 278, 22771-22780.

Vuillemenot, B. R., Rodriguez, J. F., and Hoyle, G. W. (2003). Lymphoid Tissue and Emphysema in the Lungs of Transgenic Mice Inducibly Expressing TNF-{alpha}. Am J Respir Cell Mol Biol 11, 11.

Wagner, K.-D., Wagner, N., Schley, G., Theres, H., and Scholz, H. (2003). The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). Gene 305, 217-223.

Wakabayashi, Y., Inoue, J., Takahashi, Y., Matsuki, A., Kosugi-Okano, H., Shinbo, T., Mishima, Y., Niwa, O., and Kominami, R. (2003). Homozygous deletions and point mutations of the Rit1/Bcl11b gene in [gamma]-ray induced mouse thymic lymphomas. Biochemical and Biophysical Research Communications 301, 598-603.

Wang, J., Tekle, E., Oubrahim, H., Mieyal, J. J., Stadtman, E. R., and Chock, P. B. (2003). Stable and controllable RNA interference: Investigating the physiological function of glutathionylated actin. PNAS 100, 5103-5106.

Wang, J.-H., Yun, C., Kim, S., Lee, J.-H., Yoon, G., Lee, M.-O., and Cho, H. (2003). Reactive oxygen species modulates the intracellular level of HBx viral oncoprotein. Biochemical and Biophysical Research Communications 310, 32-39.

Wang, J., Chen, Q., Corne, J., Zhu, Z., Lee, C. G., Bhandari, V., Homer, R. J., and Elias, J. A. (2003). Pulmonary Expression of Leukemia Inhibitory Factor Induces B Cell Hyperplasia and Confers Protection in Hyperoxia. J Biol Chem 278, 31226-31232.

Wang, J., Chen, G., and Pantopoulos, K. (2003). The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin. Biochem J 370, 891-899.

Wang, J., Liu, S., Haditsch, U., Tu, W., Cochrane, K., Ahmadian, G., Tran, L., Paw, J., Wang, Y., Mansuy, I., et al. (2003). Interaction of Calcineurin and Type-A GABA Receptor gamma 2 Subunits Produces Long-Term Depression at CA1 Inhibitory Synapses. J Neurosci 23, 826-760.

Wang, J., Chen, G., and Pantopoulos, K. (2003). The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin. Biochem J 370, 891-899.

Wassmann, K., Liberal, V., and Benezra, R. (2003). Mad2 phosphorylation regulates its association with Mad1 and the APC/C. EMBO J 22, 797-806.

Watcharasit, P., Bijur, G. N., Song, L., Zhu, J., Chen, X., and Jope, R. S. (2003). Glycogen Synthase Kinase-3{beta} (GSK3{beta}) Binds to and Promotes the Actions of p53. J Biol Chem 278, 48872-48879.

Webb, J. L., Ravikumar, B., Atkins, J., Skepper, J. N., and Rubinsztein, D. C. (2003). {alpha}-Synuclein Is Degraded by Both Autophagy and the Proteasome. J Biol Chem 278, 25009-25013.

Weingartner, M., Pelayo, H. R., Binarova, P., Zwerger, K., Melikant, B., de la Torre, C., Heberle-Bors, E., and Bogre, L. (2003). A plant cyclin B2 is degraded early in mitosis and its ectopic expression shortens G2-phase and alleviates the DNA-damage checkpoint. J Cell Sci 116, 487-498.

Wheadon, H., and Welham, M. J. (2003). The coupling of TEL/PDGF{beta}R to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases. Blood 102, 1480-1489.

Wheadon, H., Edmead, C., and Welham, M. J. (2003). Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2). Biochem J 376, 147-157.

Wheeler, Y. Y., Kute, T. E., Willingham, M. C., Chen, S.-Y., and Sane, D. C. (2003). Intrabody-based strategies for inhibition of vascular endothelial growth factor receptor-2: effects on apoptosis, cell growth, and angiogenesis. FASEB J, 1733-1735.

Wilkes, M. C., Murphy, S. J., Garamszegi, N., and Leof, E. B. (2003). Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor {beta} Independent of Smad2 and Smad3. Mol Cell Biol 23, 8878-8889.

Willis, A. C., Pipes, T., Zhu, J., and Chen, X. (2003). p73 can suppress the proliferation of cells that express mutant p53. Oncogene 22, 5481-5495.

Wilson, E. M., Hsieh, M. M., and Rotwein, P. (2003). Autocrine Growth Factor Signaling by Insulin-like Growth Factor-II Mediates MyoD-stimulated Myocyte Maturation. J Biol Chem 278, 41109-41113.

Wittke, I., Wiedemeyer, R., Pillmann, A., Savelyeva, L., Westermann, F., and Schwab, M. (2003). Neuroblastoma-Derived Sulfhydryl Oxidase, a New Member of the Sulfhydryl Oxidase/Quiescin6 Family, Regulates Sensitization to Interferon {gamma}-Induced Cell Death in Human Neuroblastoma Cells. Cancer Res 63, 7742-7752.

Wittmann, B. M., Wang, N., and Montano, M. M. (2003). Identification of a Novel Inhibitor of Breast Cell Growth That Is Down-Regulated by Estrogens and Decreased in Breast Tumors. Cancer Res 63, 5151-5158.

Wiznerowicz, M., and Trono, D. (2003). Conditional Suppression of Cellular Genes: Lentivirus Vector-Mediated Drug-Inducible RNA Interference. J Virol 77, 8957-8951.

Wong, S., McLaughlin, J., Cheng, D., and Witte, O. N. (2003). Cell context-specific effects of the BCR-ABL oncogene monitored in hematopoietic progenitors. Blood 101, 4088-4097.

Wong, L.-F., and Murphy, D. (2003). Adenoviral-mediated over-expression of Brn2 in the rat paraventricular nucleus: no effect on vasopressin or corticotrophin releasing factor RNA levels. Molecular and Cellular Endocrinology 200, 165-175.

WONG, S. K., SATO, S., and LAZINSKI, D. W. (2003). Elevated activity of the large form of ADAR1 in vivo: Very efficient RNA editing occurs in the cytoplasm. RNA 9, 586-1707.

Wong, L.-F., Harding, T., Uney, J., and Murphy, D. (2003). cAMP-dependent protein kinase A mediation of vasopressin gene expression in the hypothalamus of the osmotically challenged rat. Molecular and Cellular Neuroscience 24, 82-90.

Wong, A. S. T., and Gumbiner, B. M. (2003). Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin. J Cell Biol 161, 1191-1203.

Wosik, K., Antel, J., Kuhlmann, T., Bruck, W., Massie, B., and Nalbantoglu, J. (2003). Oligodendrocyte injury in multiple sclerosis: a role for p53. J Neurochem 85, 635-1707.

Wu, G., Jiang, X., Lee, W.-H., and Chen, P.-L. (2003). Assembly of Functional ALT-associated Promyelocytic Leukemia Bodies Requires Nijmegen Breakage Syndrome 1. Cancer Res 63, 2589-2595.

Wu, Y., and Marsh, J. W. (2003). Early Transcription from Nonintegrated DNA in Human Immunodeficiency Virus Infection. J Virol 77, 10376-10382.

Xing, H. R., Cordon-Cardo, C., Deng, X., Tong, W., Campodonico, L., Fuks, Z., and Kolesnick, R. (2003). Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. Nat Med 9, 1266-1268.

Xiong, J., Fan, S., Meng, Q., Schramm, L., Wang, C., Bouzahza, B., Zhou, J., Zafonte, B., Goldberg, I. D., Haddad, B. R., et al. (2003). BRCA1 Inhibition of Telomerase Activity in Cultured Cells. Mol Cell Biol 23, 8668-8690.

Xu, Z.-L., Mizuguchi, H., Mayumi, T., and Hayakawa, T. (2003). Regulated gene expression from adenovirus vectors: a systematic comparison of various inducible systems. Gene 309, 145-151.

Xu, L. L., Shi, Y., Petrovics, G., Sun, C., Makarem, M., Zhang, W., Sesterhenn, I. A., McLeod, D. G., Sun, L., Moul, J. W., and Srivastava, S. (2003). PMEPA1, an Androgen-regulated NEDD4-binding Protein, Exhibits Cell Growth Inhibitory Function and Decreased Expression during Prostate Cancer Progression. Cancer Res 63, 4299-4304.

Xu, Y.-X., Hirose, Y., Zhou, X. Z., Lu, K. P., and Manley, J. L. (2003). Pin1 modulates the structure and function of human RNA polymerase II. Genes Dev 17, 2765-2776.

Yamada, T., Yamazaki, H., Yamane, T., Yoshino, M., Okuyama, H., Tsuneto, M., Kurino, T., Hayashi, S.-I., and Sakano, S. (2003). Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells. Blood 101, 2227-2234.

Yamada, T., Mori, Y., Hayashi, R., Takada, M., Ino, Y., Naishiro, Y., Kondo, T., and Hirohashi, S. (2003). Suppression of Intestinal Polyposis in Mdr1-deficient ApcMin/+ Mice. Cancer Res 63, 895-901.

Yamamoto, M., Wada, N., Kitabatake, Y., Watanabe, D., Anzai, M., Yokoyama, M., Teranishi, Y., and Nakanishi, S. (2003). Reversible Suppression of Glutamatergic Neurotransmission of Cerebellar Granule Cells In Vivo by Genetically Manipulated Expression of Tetanus Neurotoxin Light Chain. J Neurosci 23, 6759-6767.

Yang, J.-J. (2003). A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle. Biochemical and Biophysical Research Communications 301, 71-77.

Yang, L., Naltner, A., and Yan, C. (2003). Overexpression of Dominant Negative Retinoic Acid Receptor {alpha} Causes Alveolar Abnormality in Transgenic Neonatal Lungs. Endocrinology 144, 3004-3011.

Yang, H.-Y., Wen, Y.-Y., Chen, C.-H., Lozano, G., and Lee, M.-H. (2003). 14-3-3{sigma} Positively Regulates p53 and Suppresses Tumor Growth. Mol Cell Biol 23, 7096-7107.

Yang, T., McNally, B. A., Ferrone, S., Liu, Y., and Zheng, P. (2003). A Single-nucleotide Deletion Leads to Rapid Degradation of TAP-1 mRNA in a Melanoma Cell Line. J Biol Chem 278, 15291-15296.

Yang, Y., Wang, X., Dong, T., Kim, E., Lin, W.-J., and Chang, C. (2003). Identification of a Novel Testicular Orphan Receptor-4 (TR4)-associated Protein as Repressor for the Selective Suppression of TR4-mediated Transactivation. J Biol Chem 278, 7709-7717.

Yasuda, J., Tsuchiya, A., Yamada, T., Sakamoto, M., Sekiya, T., and Hirohashi, S. (2003). Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells. Biochemical and Biophysical Research Communications 308, 227-233.

Yeh, M.-G., Ziober, B. L., Liu, B., Lipkina, G., Vizirianakis, I. S., and Kramer, R. H. (2003). The {beta}1 Cytoplasmic Domain Regulates the Laminin-binding Specificity of the {alpha}7X1 Integrin. Mol Biol Cell 14, 3507-3518.

Yen, K., Gitsham, P., Wishart, J., Oliver, S. G., and Zhang, N. (2003). An improved tetO promoter replacement system for regulating the expression of yeast genes. Yeast 20, 1255-1262.

YIN, Y.-J., SALAH, Z., MAOZ, M., RAM, S. C. E., OCHAYON, S., NEUFELD, G., KATZAV, S., and BAR-SHAVIT, R. (2003). Oncogenic transformation induces tumor angiogenesis: a role for PAR1 activation. FASEB J 17, 163-174.

Yin, M.-J., Shao, L., Voehringer, D., Smeal, T., and Jallal, B. (2003). The Serine/Threonine Kinase Nek6 Is Required for Cell Cycle Progression through Mitosis. J Biol Chem 278, 52454-52460.

Ying, C., De Clercq, E., and Neyts, J. (2003). Selective inhibition of hepatitis B virus replication by RNA interference. Biochemical and Biophysical Research Communications 309, 482-484.

Yoo, Y.-G., Oh, S. H., Park, E. S., Cho, H., Lee, N., Park, H., Kim, D. K., Yu, D.-Y., Seong, J. K., and Lee, M.-O. (2003). Hepatitis B Virus X Protein Enhances Transcriptional Activity of Hypoxia-inducible Factor-1{alpha} through Activation of Mitogen-activated Protein Kinase Pathway. J Biol Chem 278, 39076-39084.

Yoshida, K., and Inoue, I. (2003). Conditional expression of MCM7 increases tumor growth without altering DNA replication activity. FEBS Letters 553, 213-217.

Yoshida, H., Matsui, T., Hosokawa, N., Kaufman, R. J., Nagata, K., and Mori, K. (2003). A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response. Developmental Cell 4, 265-271.

You, X.-M., Mungrue, I. N., Kalair, W., Afroze, T., Ravi, B., Sadi, A. M., Gros, R., and Husain, M. (2003). Conditional Expression of a Dominant-Negative c-Myb in Vascular Smooth Muscle Cells Inhibits Arterial Remodeling After Injury. Circ Res 92, 314-760.

Yu, J., Wang, Z., Kinzler, K. W., Vogelstein, B., and Zhang, L. (2003). PUMA mediates the apoptotic response to p53 in colorectal cancer cells. PNAS 100, 1931-1936.

Yu, C., Rahmani, M., Dai, Y., Conrad, D., Krystal, G., Dent, P., and Grant, S. (2003). The Lethal Effects of Pharmacological Cyclin-dependent Kinase Inhibitors in Human Leukemia Cells Proceed through a Phosphatidylinositol 3-Kinase/Akt-dependent Process. Cancer Res 63, 1822-1833.

Yu, D. S., Sonoda, E., Takeda, S., Huang, C. L. H., Pellegrini, L., Blundell, T. L., and Venkitaraman, A. R. (2003). Dynamic Control of Rad51 Recombinase by Self-Association and Interaction with BRCA2. Molecular Cell 12, 1029-1041.

Yu, C., Rahmani, M., Almenara, J., Sausville, E. A., Dent, P., and Grant, S. (2003). Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process. Oncogene 1, 1.

Zegers, M. M. P., Forget, M.-A., Chernoff, J., Mostov, K. E., ter Beest, M. B. A., and Hansen, S. H. (2003). Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J 22, 4155-4165.

Zhang, A.-S., Davies, P. S., Carlson, H. L., and Enns, C. A. (2003). Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation. PNAS 100, 9500-9505.

Zhang, N., Osborn, M., Gitsham, P., Yen, K., Miller, J. R., and Oliver, S. G. (2003). Using yeast to place human genes in functional categories. Gene 303, 121-129.

Zhang, X., Multani, A. S., Zhou, J.-H., Shay, J. W., McConkey, D., Dong, L., Kim, C.-S., Rosser, C. J., Pathak, S., and Benedict, W. F. (2003). Adenoviral-mediated Retinoblastoma 94 Produces Rapid Telomere Erosion, Chromosomal Crisis, and Caspase-dependent Apoptosis in Bladder Cancer and Immortalized Human Urothelial Cells but not in Normal Urothelial Cells. Cancer Res 63, 760-765.

Zhang, H., Palmer, R., Gao, X., Kreidberg, J., Gerald, W., Hsiao, L., Jensen, R. V., Gullans, S. R., and Haber, D. A. (2003). Transcriptional Activation of Placental Growth Factor by the Forkhead/Winged Helix Transcription Factor FoxD1. Current Biology 13, 1625-1629.

Zhang, X.-L., Zhang, D., Michel, F. J., Blum, J. L., Simmen, F. A., and Simmen, R. C. M. (2003). Selective Interactions of Kruppel-like Factor 9/Basic Transcription Element-binding Protein with Progesterone Receptor Isoforms A and B Determine Transcriptional Activity of Progesterone-responsive Genes in Endometrial Epithelial Cells. J Biol Chem 278, 21474-21482.

Zhang, F., Pao, W., Umphress, S. M., Jakowlew, S. B., Meyer, A. M., Dwyer-Nield, L. D., Nielsen, L. D., Takeda, K., Gelfand, E. W., Fisher, J. H., et al. (2003). Serum Levels of Surfactant Protein D Are Increased in Mice with Lung Tumors. Cancer Res 63, 5889-5894.

Zhang, H. M., Yuan, J., Cheung, P., Luo, H., Yanagawa, B., Chau, D., Stephan-Tozy, N., Wong, B. W., Zhang, J., Wilson, J. E., et al. (2003). Overexpression of Interferon-{gamma}-inducible GTPase Inhibits Coxsackievirus B3-induced Apoptosis through the Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway and Inhibition of Viral Replication. J Biol Chem 278, 33011-33019.

Zhao, X., Lamphear, B. J., Xiong, D., Knowlton, K., and Rhoads, R. E. (2003). Protection of Cap-dependent Protein Synthesis in Vivo and in Vitro with an eIF4G-1 Variant Highly Resistant to Cleavage by Coxsackievirus 2A Protease. J Biol Chem 278, 4449-4457.

Zhao, G. Q., Zhang, Y., Hoon, M. A., Chandrashekar, J., Erlenbach, I., Ryba, N. J. P., and Zuker, C. S. (2003). The Receptors for Mammalian Sweet and Umami Taste. Cell 115, 255-266.

Zheng, X., Kelley, K., Elnakat, H., Yan, W., Dorn, T., and Ratnam, M. (2003). mRNA Instability in the Nucleus Due to a Novel Open Reading Frame Element Is a Major Determinant of the Narrow Tissue Specificity of Folate Receptor {alpha}. Mol Cell Biol 23, 2202-2212.