Newsletter December 2009
Assignment Agreement signed with AMC/STW
TET Systems, AMC (Academic Medical Center) and STW Technology Foundation entered into an assignment agreement. Previously, scientists at the AMC had developed a new series of Tet-On transactivators with improved properties. Under the terms of the agreement, eight international patent applications covering these novel transactivators were assigned to TET Systems for commercialization. The acquisition of these patent applications broadens TET Systems` IP portfolio and makes TET Systems the only source for licensing all relevant IP covering the Tet Technology.
New license agreements signed
This year TET Systems has signed a record number of new license agreements. New licensees comprise Takara Bio, BioFocus DPI, and most recently, Novo Nordisk to name a select few. This year, TET Systems filed a law suit for Patent Infringement in the US against Pharmasset. As part of the settlement agreement, TET Systems agreed to dismiss further legal action while Pharmasset agreed to take a license for the Tet Technology for precise and efficient control of gene expression in higher eukaryotes.
TET Systems Conference Activities 2009
TET Systems successfully attended this year`s Bio International Convention in Atlanta and Bio-Europe in Vienna. TET`s major focus at these conferences was on partnering new technologies and on identifying new potential licensees for the Tet Technology.
This year`s Conference highlight was a sponsored workshop during the "First EMBO Conference" in Amsterdam, the first annual life science conference organized by EMBO. TET Systems together with its partner Clontech, sponsored a scientific symposium titled "The Tet Technology and its Impact on Modern Life Sciences". After an introduction by Prof. H. Bujard, one of the inventors of the Tet Technology, several distinguished scientists (R.Jaenisch, MIT, D.Felsher, Stanford University and L.Alphey, Oxitec) presented data on exciting new applications of the Tet Technology.
In 2010 TET Systems plans to attend Bio International Convention in Chicago in May and BioEurope2010 in Munich.
New Publication Highlight
M.S.H. Ko and colleagues recently published a highly interesting paper on early responses of gene regulatory networks. Placing 50 transcription factors encoded in the mouse genome systematically under Tet control in a highly defined chromosomal locus (ROSA-Tet), they generated ES cell lines in which one transcription factor can be induced at a time, enabling analyses of resulting transcription factor network changes. These highly standardized ES cell lines which are freely provided to the academic research community by the authors have already documented that not all transcription factors are equal and will be valuable research tools to gain further insights into gene regulatory networks.
New online tool to search Tet bibliography
Early next year, a new tool to search our Tet bibliography online will become available to visitors of our website. This new tool will enable interested parties to search the entire Tet literature database without a required previous download. Our database meanwhile comprises 6,200 references of peer reviewed scientific articles on applications of the Tet Technology underlining the importance of the Tet Technology as the most widely used inducible gene expression system. The Tet bibliography is the most comprehensive list of Tet references and is updated on a yearly basis as a free service that TET Systems provides to its licensees and the scientific community.
Holiday Notice
Our offices will be closed starting on Dec. 24th until Jan. 4th, 2010. We wish you all an enjoyable Holiday Season and a great start into a successful New Year.
To our Readers
We are continuously trying to improve our services and information to all users of the Tet Technology. We appreciate your comments and feed-back regarding this Newsletter and all other proposals regarding our homepage. Please send your comments/proposals to info@tet-systems.com.
To download, click here.
Newsletter July 2009
TET Systems attends the first "EMBO Meeting" in Amsterdam
TET Systems will attend the first EMBO Meeting in Amsterdam both as exhibitor and sponsor of a scientific symposium on Monday, August 31: "The Tet Technology and its Impact on Modern Life Sciences" which we organize together with our partner Clontech. A prominent group of speakers (R.Jaenisch, D.Felsher and L.Alphey) will summarize recent advances in the fields of stem cell biology, cancer disease and progression and sterile insect technology. Prof. H. Bujard, one of the inventors of the Tet Technology, will provide an introductory overview. Please join us at this interesting workshop. We also look forward to meeting our customers, partners and all interested parties in Amsterdam.
New marketing agreement signed with Takara Bio
Takara Bio Inc., an innovative biotechnology company based in Japan, listed on the Tokyo Stock Exchange, and TET Systems Holding, a privately-held, German-based biotech company have entered into a marketing agreement in May. Takara Bio Inc. has been engaged in development, manufacturing, and sales of research reagents and equipment to the life science research market in Japan as well as other countries, and has extensive experience in establishing various types of alliances with Japanese companies and public institutions. Takara Bio Inc. will use this experience and its sales and marketing expertise to exclusively market the Tet Technology for TET Systems Holding in Japan.
TET`s web based services
On its home page (www.tet-systems.com), TET Systems offers a range of services for registered users including reviews of recently published scientific articles. We also provide a comprehensive list of transgenic animals and all scientific publications using the Tet Technology.
Publication Highlights
This section provides regular summaries and/or reviews of scientific manuscripts which we consider of particular interest to the users of the Tet Technology. Publications are selected that cover applications of our technology in a "hot" field of research (e.g. RNAi, iPS or sterile insect control) or novel and innovative applications of our Tet Technology. We also highlight scientific publications describing break-through research where the Tet Technology was instrumental for new and groundbreaking insights in an established field.
List of Tet transgenic mouse lines updated
A first update of the table of Tet transgenic mice is now available online under "SUPPORT". This comprehensive list is based on a recent literature search for new transgenic mouse lines expressing either Tet transactivators (e.g. Tet-On, Tet-Off or Tet-On/Off Advanced) or mice expressing various genes under Tet control. The table also provides referencing of the original publication to facilitate understanding of the genealogy of the Tet transgenic mouse. The availability of these transgenic mouse lines from our partners, certified repositories like "the Jackson Labs","EMMA" or "Riken", are also provided.
New Tet bibliography online
The new, comprehensive list of Tet references (scientific articles using our Tet Technology) is available for download now. This updated list comprises more than 6200 peer reviewed scientific articles underlining the importance of the Tet Technology as the most widely used inducible gene expression system. The Tet bibliography is updated on a yearly basis and covers original work. Review articles are only included when the Tet gene expression systems are the focus of the review.
To our Readers
We are continuously trying to improve our services and information to all users of the Tet Technology. We appreciate your comments and feed-back regarding this Newsletter and all other proposals regarding our homepage. Please send your comments/proposals to info@tet-systems.com.
To download, click here.